Remote Global Clinical Trial Lead (Contract)

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company; Boston (MA); Remote; USD 96,000 - 138,000; Full time

Benefits offered by this job

401(k)

Wellness programs

Medical plans (PPO/EPO)

Dental and vision coverage after 30 d

Job summary

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is seeking a Senior Clinical Trial Manager (Contract) to lead global studies from startup through closeout. This contract-to-hire role focuses on operational strategy, timelines, budgets, vendor oversight, and quality, ensuring studies are conducted efficiently and in compliance.

Based in the US with remote work and occasional travel, you will manage CROs, cross-functional teams, TMF readiness, and regulatory

Qualifications

• 8+ years of clinical research experience, including 5+ years of clinical trial management experience within a sponsor or CRO environment.
• Experience in standard clinical pharmacology package studies such as First in Human, DDI, Bioavailability, Bioequivalence, etc.
• Demonstrated experience independently leading Phase 1 studies, global Phase II and/or Phase III clinical trials.

Responsibilities

• Lead the planning, execution, and oversight of global clinical trials from startup through closeout.
• Serve as the primary operational lead for assigned studies, driving cross-functional alignment and execution.
• Develop and manage study timelines, budgets, enrollment forecasts, risk mitigation plans, and key performance metrics.
• Oversee CROs and external vendors to ensure delivery against scope, quality standards, timelines, and budget.
• Drive critical study milestones, including site activation, enrollment, database lock, and study closeout.
• Review and approve study plans, vendor deliverables, and trial documentation to ensure compliance with protocol, GCP, and regulatory requirements.
• Identify operational risks and issues, implement mitigation strategies, and elevate as appropriate.
• Lead study team meetings and provide regular updates to stakeholders and senior management.
• Ensure Trial Master File (TMF) quality, completeness, and inspection readiness throughout the study lifecycle.
• Support regulatory submissions, audits, inspections, and Health Authority interactions.
• Contribute to process improvements and mentor junior clinical operations team members as needed.
• Collaborate effectively with global teams, investigators, CROs, and vendors across multiple regions.

Skills

Clinical research experience

Clinical trial management

Phase 1 studies

CRO/vendor management

Regulatory interactions

Education

Bachelor's degree in science or health-related field

Job description

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is seeking a Senior Clinical Trial Manager (Contract) to lead global studies from startup through closeout. This contract-to-hire role focuses on operational strategy, timelines, budgets, vendor oversight, and quality, ensuring studies are conducted efficiently and in compliance.

Based in the US with remote work and occasional travel, you will manage CROs, cross-functional teams, TMF readiness, and regulatory