Proteomics Scientist: Spatial & Single-Cell LC/MS

Alnylam Pharmaceuticals; United States; On-site; USD 90,000 - 130,000; Full time

Job summary

Alnylam Pharmaceuticals in Cambridge, MA seeks a Proteomics Scientist to lead LC/MS-based workflows for spatial, single-cell, and subcellular proteomics. The role emphasizes method development, data analysis, and collaboration within a fast-paced translational team working on RNAi therapeutics.

The position focuses on on-site work in Cambridge, MA, requiring strong communication, a PhD in a quantitative field, and experience with Orbitrap instruments.

Qualifications

• PhD in Bioengineering, Chemical Engineering, or related quantitative field.
• 0-3 years of experience in biopharma setting.
• Expertise in LC/MS instrumentation and proteomics method development.
• Strong computational background with Python/ Matlab/ R.
• Excellent communication skills (written and oral).
• Self-motivated and thrive in a fast-paced team environment.
• Familiarity with high-throughput sample preparation automation is preferred.
• Strong ability to work independently and in a team.

Responsibilities

• Drive sample preparation and LC/MS method development for novel workflows including single cell, spatial, and subcellular proteomics.
• Develop data analysis and interpretation workflows optimized for next-gen proteomics.
• Collaborate with an interdisciplinary team to identify and characterize receptors for targeted delivery.
• Leverage AI tools to inform receptor prediction based on protein sequence and structure.
• Maintain timely documentation and transparently communicate results with stakeholders.

Skills

LC/MS

Proteomics method development

Orbitrap experience

Python/ Matlab/ R

Cloud computing / HPC

Scientific communication

Independent team player

Education

PhD in Bioengineering, Chemical Engineering, or related field

Tools

Thermo Orbitrap

Python

Matlab

R

Job description

Alnylam Pharmaceuticals in Cambridge, MA seeks a Proteomics Scientist to lead LC/MS-based workflows for spatial, single-cell, and subcellular proteomics. The role emphasizes method development, data analysis, and collaboration within a fast-paced translational team working on RNAi therapeutics.

The position focuses on on-site work in Cambridge, MA, requiring strong communication, a PhD in a quantitative field, and experience with Orbitrap instruments.