Associate Scientist II, Protein Sciences

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 65,000 - 90,000; Full time

Job summary

Alnylam Pharmaceuticals in Cambridge, MA is seeking an Associate Scientist-II to join the protein sciences team, contributing to protein production and conjugation efforts.

You will work with biologists, chemists, and pharmacologists to advance research programs across multiple modalities and deliver high-quality proteins and conjugates in a fast-paced environment.

Qualifications

• BS/MS degree in chemistry, chemical engineering, biochemistry or related field with 0–1 years of lab experience.
• Experience with modern bioconjugation chemistry and analytical techniques.
• Experience with instrumentation such as Agilent and AKTA HPLC systems, TFF, and UV-Vis spectrometry.
• Experience with protein and protein conjugate analysis (affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV-Vis spectroscopy).
• Experience developing new chromatographic methods is a plus.

Responsibilities

• Work with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
• Design and perform protein conjugation experiments to support in vitro and in vivo evaluations.
• Support purification, buffer exchange, characterization, and QC of protein and oligonucleotide conjugates using UV-Vis spectroscopy and HPLC.
• Maintain laboratory infrastructure and equipment.
• Communicate plans and data to cross-functional teams.

Skills

Bioconjugation chemistry

Analytical techniques

Protein analysis

Education

BS/MS in chemistry/biochemistry/chemical engineering or related field

Tools

Agilent HPLC

AKTA systems

TFF

UV-Vis spectrometry

Job description

Overview

We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein purification, bio conjugation and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment. The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities

This lab-based position is onsite and will be located in Cambridge, MA.

Key Responsibilities

• Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
• Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
• Support the purification, buffer exchange, characterization, and QC of protein and oligonucleotide conjugates by utilizing UV-Vis spectroscopy and HPLC
• Contribute to the maintenance of laboratory infrastructure and equipments.
• Support group organization, productivity, and expertise through collaboration and idea exchange.
• Assist in optimizing inventory system for proteins and protein conjugates.
• Meet quality, quantity, and timeline expectations for all assigned projects.
• Support discovery efforts in protein sciences.
• Maintain accurate and complete electronic notebook records.
• Communicate experimental plans and data to multiple cross-functional scientific teams.

Qualifications

• BS/MS degree in chemistry, chemical engineering, biochemistry, or a related field with 0-1 years of relevant laboratory experience in a biopharma or academic setting.
• Experience with modern bioconjugation chemistry and analytical techniques.
• Experience with instrumentation such as Agilent and AKTA HPLC systems, TFF, and UV-Vis spectrometry.
• Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV-Vis spectroscopy)
• Experience developing new chromatographic methods is a plus.
• Passion for driving projects from the bench, independently contributing to research goals, and solving challenging problems.
• Detail-oriented, self-motivated, and comfortable working on highly technical projects in a multidisciplinary team setting.
• Effective written and oral communication skills.

About Alnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's CandidatePrivacy Noticeregarding how Alnylam handles Personal Data you provide with your application for employment.