Process Development Scientist: Scale-Up & Packed-Bed Chromatography

Advantage Technical; Cambridge (MA); On-site; USD 70,000 - 116,000; Full time

Job summary

Advantage Technical in Cambridge, MA is seeking a hands‑on Scientist in Process Sciences to advance oligonucleotide manufacturing processes, including development, characterization, optimization, and scale‑up, applying mass transfer and reaction engineering to a solid‑phase synthesis platform.

The role emphasizes working with packed‑bed reactors, large‑scale chromatography, and process scale‑up, with collaboration across Analytical Development, Manufacturing, QA, and external CMOs to transfer

Qualifications

• Master’s degree in chemistry, chemical engineering, biochemical engineering, or a closely related discipline.
• Hands‑on experience with packed‑bed reactor systems or related solid‑liquid processing equipment.
• Experience with large‑scale chromatography, including column operation beyond routine MPLC.
• Strong understanding of mass transfer, reaction engineering, fluid flow, and interactions among fluids, reagents, and solid particles.
• Demonstrated experience developing, characterizing, optimizing, or scaling manufacturing processes.
• Experience troubleshooting process failures and translating findings into process improvements.
• Experience with chromatography resins, polymer systems, solid supports, catalysts, or related materials.
• Ability to author clear technical protocols and reports and present findings to technical audiences.

Responsibilities

• Contribute to development, optimization, characterization, and scale‑up of oligonucleotide manufacturing processes.
• Design and execute lab studies involving packed‑bed reactors, chromatography columns, resins, and related solid‑liquid systems.
• Apply mass‑transfer and reaction‑engineering principles to improve process performance.
• Support characterization for small‑molecule and oligonucleotide APIs.
• Troubleshoot process failures, identify root causes, and propose solutions.
• Assist transfer of processes from lab to larger scale manufacturing.
• Contribute to management and optimization of internal and external manufacturing processes.
• Author and review technical protocols, development reports, study summaries, and process‑characterization docs.
• Prepare, edit, and review manufacturing documentation per procedures and regulatory requirements.
• Collaborate across Analytical Development, Manufacturing, QA/QC, and external CMO/CRO partners on transfer and optimization.
• Analyze results, communicate conclusions, and present findings to internal and external teams.
• Participate in strategic discussions on process development, scale‑up, and manufacturing readiness.

Skills

Packed-bed reactors

Large-scale chromatography

Mass transfer

Reaction engineering

Process scale-up

Solid‑liquid interactions

Education

Master's degree in chemistry or chemical engineering or related field

Tools

Chromatography columns

Solid‑liquid processing equipment

Job description

Advantage Technical in Cambridge, MA is seeking a hands‑on Scientist in Process Sciences to advance oligonucleotide manufacturing processes, including development, characterization, optimization, and scale‑up, applying mass transfer and reaction engineering to a solid‑phase synthesis platform.

The role emphasizes working with packed‑bed reactors, large‑scale chromatography, and process scale‑up, with collaboration across Analytical Development, Manufacturing, QA, and external CMOs to transfer