Principal Information System Engineer

Treelinebiosciences; Watertown (MA); On-site; USD 180,000 - 197,000; Full time

Job summary

Treeline Biosciences in Watertown, MA seeks an experienced Principal Information System Engineer to lead IT operations, manage modern workplace tech, and troubleshoot complex issues across multiple countries.

Reporting to the Director of IT Operations, the role focuses on cloud, identity, and endpoint management, with a hands-on approach and collaboration with MSPs and in-house engineers. A biotech startup background is a plus.

Qualifications

• 8-10+ years of experience in systems administration, endpoint management, identity management, or IT operations.
• Experience with Windows, Mac, databases, storage, security, networking, and public clouds.
• Hands-on experience with Microsoft 365 Administration, Intune, Entra ID, and MFA.
• Experience with Okta and endpoint security configurations.
• Strong troubleshooting, problem-solving, and communication skills.
• Biotech startup or biopharmaceutical experience a plus.

Responsibilities

• Serve as the primary escalation point for IT, providing hands-on end-user support.
• Lead complex technical initiatives and drive projects.
• Advise Director of IT Operations on tooling, standards, and vendor issues.
• Administer and optimize cloud-based enterprise tech including endpoint, identity, and security.
• Manage Microsoft 365, Intune, and Entra ID environments with CA policies.
• Manage identity via Okta and MFA to protect Treeline systems.
• Develop PowerShell scripts to automate tasks.
• Collaborate with engineers and MSPs across departments and countries.
• Maintain documentation and knowledge base per ITSM processes.
• Work with local/remote teams and vendors to improve IT solutions.

Skills

Windows

Mac

Databases

Storage

Security

Networking

Public clouds

Troubleshooting

Documentation

Communication

Education

Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent work experience

Tools

Microsoft 365 Administration

Microsoft Intune

ManageEngine Endpoint Central

Microsoft Entra ID

Okta

PowerShell

MFA configuration

Job description

Summary

We are seeking an experienced and customer-focused Principal Information System Engineer to join our IT team. The ideal candidate will have strong experience managing modern workplace technologies and troubleshooting complex technical issues. This role reports to our Director, IT Operations and will work closely with both our in-house engineers and Managed Service Providers (MSPs) supporting Treeliners from every department across multiple countries.

Responsibilities

• Serve as the primary technical escalation point for the IT organization, including providing hands-on support to end users as needed.
• Hands-on leadership for complex technical initiatives.
• Serve as a secondary technical decision-maker for IT Operations, providing recommendations to the Director on tooling, standards, and vendor issues.
• Administer, support, and optimize cloud-based enterprise technologies, including endpoint, identity, and security management solutions.
• Manage modern workplace technologies and troubleshoot complex technical issues.
• Administer and maintain Microsoft 365, Microsoft Intune, and Microsoft Entra ID environments, including Conditional Access Policies and endpoint security configurations.
• Manage identity and access solutions, including Okta and Multi-Factor Authentication (MFA), to safeguard Treeline systems and data.
• Develop and maintain PowerShell scripts to automate routine administrative tasks and improve operational efficiency.
• Partner with in-house engineers and MSPs to support employees across multiple departments and countries.
• Maintain accurate documentation, ticket updates, and knowledge base articles in accordance with established ITSM processes.
• Collaborate with local and remote coworkers and vendors to design, implement, and continuously improve IT solutions.

Qualifications

• Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent work experience.
• 8-10+ years of experience in systems administration, endpoint management, identity management, or IT operations.
• A broad range of overall IT experience, including Windows, Mac, Databases, Storage, Security, Networking and public clouds.
• Strong hands-on experience with the following or similar:
• Microsoft 365 Administration
• Microsoft Intune
• ManageEngine Endpoint Central
• Microsoft Entra ID, including Conditional Access Policies
• Okta
• Endpoint security and device management
• Multi-Factor Authentication (MFA)
• PowerShell (Basic to Intermediate)
• Strong troubleshooting, problem-solving, and analytical skills.
• A track record of taking ownership in issue resolution. No problem is too big or too small.
• Organized and detail orientated.
• Excellent written and verbal communication skills, including clear documentation, ticket updates, and knowledge base contributions.
• Familiarity with ticketing systems and ITSM processes
• Experience working collaboratively with coworkers and vendors, both local and remote, while also being effective working independently.
• You are curious, creative, and innovative and want to continuously improve our processes.
• Previous experience working in a biotech startup or biopharmaceutical.
• Related certifications are a plus
• Ability to explain technical issues clearly to non-technical users
• Patient, customer-focused mindset with a commitment to service quality
• Ability to prioritize tasks and manage multiple issues simultaneously

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $180,250 to $196,751. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.