Principal Information System Engineer

Treeline; Watertown (MA); On-site; USD 180,000 - 197,000; Full time

Job summary

Treeline seeks an experienced Principal Information System Engineer to lead IT operations and manage modern workplace technologies across departments and countries.

You will be the primary escalation point, oversee complex initiatives, and drive automation through PowerShell. Strong collaboration with MSPs and in-house teams is essential, with emphasis on security, CA policies, and documentation.

Qualifications

• Requires 8–10+ years in systems administration or IT operations.
• Experience with Windows, Mac, databases, storage, security, networking, and clouds.
• Hands-on setup and maintenance of M365, Intune, Entra ID and Okta.
• Strong troubleshooting, ownership mindset, and clear documentation.
• Biotech startup or biopharma experience is a plus; security-minded.

Responsibilities

• Serve as escalation point and provide end-user support as needed.
• Lead complex technical initiatives and advise on tooling and standards.
• Administer and optimize cloud-based technologies and identity management.
• Manage M365, Intune, Entra ID environments and CA policies.
• Develop PowerShell scripts to automate tasks and improve efficiency.
• Collaborate with engineers and MSPs across departments and countries.
• Maintain documentation and ITSM ticket updates.

Skills

Windows administration

Mac administration

Troubleshooting

PowerShell

Documentation

Communication

Time management

Collaboration

Curiosity and innovation

Education

Bachelor's degree in IT/CS or equivalent

Tools

Microsoft 365

Microsoft Intune

Microsoft Entra ID

Okta

ManageEngine Endpoint Central

Job description

Summary

We are seeking an experienced and customer-focused

Summary

We are seeking an experienced and customer-focused Principal Information System Engineer to join our IT team. The ideal candidate will have strong experience managing modern workplace technologies and troubleshooting complex technical issues. This role reports to our Director, IT Operations and will work closely with both our in-house engineers and Managed Service Providers (MSPs) supporting Treeliners from every department across multiple countries.

Responsibilities

• Serve as the primary technical escalation point for the IT organization, including providing hands-on support to end users as needed.
• Hands-on leadership for complex technical initiatives.
• Serve as a secondary technical decision-maker for IT Operations, providing recommendations to the Director on tooling, standards, and vendor issues.
• Administer, support, and optimize cloud-based enterprise technologies, including endpoint, identity, and security management solutions.
• Manage modern workplace technologies and troubleshoot complex technical issues.
• Administer and maintain Microsoft 365, Microsoft Intune, and Microsoft Entra ID environments, including Conditional Access Policies and endpoint security configurations.
• Manage identity and access solutions, including Okta and Multi-Factor Authentication (MFA), to safeguard Treeline systems and data.
• Develop and maintain PowerShell scripts to automate routine administrative tasks and improve operational efficiency.
• Partner with in-house engineers and MSPs to support employees across multiple departments and countries.
• Maintain accurate documentation, ticket updates, and knowledge base articles in accordance with established ITSM processes.
• Collaborate with local and remote coworkers and vendors to design, implement, and continuously improve IT solutions.

Qualifications

• Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent work experience.
• 8-10+ years of experience in systems administration, endpoint management, identity management, or IT operations.
• A broad range of overall IT experience, including Windows, Mac, Databases, Storage, Security, Networking and public clouds.
• Strong hands-on experience with the following or similar:
• Microsoft 365 Administration
• Microsoft Intune
• ManageEngine Endpoint Central
• Microsoft Entra ID, including Conditional Access Policies
• Okta
• Endpoint security and device management
• Multi-Factor Authentication (MFA)
• PowerShell (Basic to Intermediate)
• Strong troubleshooting, problem-solving, and analytical skills.
• A track record of taking ownership in issue resolution. No problem is too big or too small.
• Organized and detail orientated.
• Excellent written and verbal communication skills, including clear documentation, ticket updates, and knowledge base contributions.
• Familiarity with ticketing systems and ITSM processes
• Experience working collaboratively with coworkers and vendors, both local and remote, while also being effective working independently.
• You are curious, creative, and innovative and want to continuously improve our processes.
• Previous experience working in a biotech startup or biopharmaceutical.
• Related certifications are a plus
• Ability to explain technical issues clearly to non-technical users
• Patient, customer-focused mindset with a commitment to service quality
• Ability to prioritize tasks and manage multiple issues simultaneously

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $180,250 to $196,751. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please Be Aware Of Recruitment Fraud And Related Job Scams, Where Scammers Present Themselves As Recruiters But Are Seeking To Steal Money Or Personal Information. Keep The Following In Mind To Protect Yourself

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through RingCentral, Skype or Telegram.
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)

The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.