Principal Information System Engineer

Treeline Biosciences; Watertown (MA); On-site; USD 180,000 - 197,000; Full time

Job summary

Treeline Biosciences in Watertown, MA, seeks a Principal Information System Engineer to lead advanced IT operations across departments and countries. You will manage cloud-based tech, identity platforms, and endpoint security while developing automation scripts.

You will partner with in-house engineers and MSPs, maintaining ITSM processes and documentation. A biotech startup background and strong communication skills are highly valued.

Qualifications

• Bachelor’s degree in Information Technology, Computer Science, or related field, or equivalent work experience.
• 8–10+ years in systems administration, endpoint management, identity management, or IT operations.
• Broad IT experience across Windows, Mac, Databases, Storage, Security, Networking and public clouds.
• Hands-on experience with Microsoft 365 Administration, Entra ID (CA policies), Okta, endpoint security, PowerShell.
• Strong troubleshooting, problem-solving, and analytical skills; ownership mindset.
• Biotech startup or biopharmaceutical experience is a plus.
• Ability to explain technical issues clearly to non-technical users.
• Patient, customer-focused mindset; ability to prioritize multiple issues.

Responsibilities

• Serve as the primary escalation point for the IT organization and provide hands-on support as needed.
• Lead complex technical initiatives with hands-on leadership.
• Recommend tooling, standards, and vendor considerations to IT Operations Director.
• Administer and optimize cloud-based enterprise tech including endpoint, identity, and security mgmt.
• Manage Microsoft 365, Intune, and Entra ID environments with Conditional Access policies.
• Manage identity solutions (Okta) and MFA to protect Treeline systems and data.
• Develop PowerShell scripts to automate routine tasks and improve efficiency.
• Collaborate with in-house engineers and MSPs across departments and countries.
• Maintain documentation, tickets, and knowledge base per ITSM processes.
• Design and implement IT solutions with local and remote teams.

Skills

Microsoft 365 Admin

Entra ID

Okta

PowerShell

Endpoint security

ITSM

Education

Bachelor's degree in IT/CS or equivalent

Tools

Microsoft Intune

Microsoft Entra ID

Okta

Job description

We are seeking an experienced and customer-focused Principal Information System Engineer to join our IT team. The ideal candidate will have strong experience managing modern workplace technologies and troubleshooting complex technical issues. This role reports to our Director, IT Operations and will work closely with both our in-house engineers and Managed Service Providers (MSPs) supporting Treeliners from every department across multiple countries.

Responsibilities

• Serve as the primary technical escalation point for the IT organization, including providing hands-on support to end users as needed.
• Hands-on leadership for complex technical initiatives.
• Serve as a secondary technical decision-maker for IT Operations, providing recommendations to the Director on tooling, standards, and vendor issues.
• Administer, support, and optimize cloud-based enterprise technologies, including endpoint, identity, and security management solutions.
• Manage modern workplace technologies and troubleshoot complex technical issues.
• Administer and maintain Microsoft 365, Microsoft Intune, and Microsoft Entra ID environments, including Conditional Access Policies and endpoint security configurations.
• Manage identity and access solutions, including Okta and Multi-Factor Authentication (MFA), to safeguard Treeline systems and data.
• Develop and maintain PowerShell scripts to automate routine administrative tasks and improve operational efficiency.
• Partner with in-house engineers and MSPs to support employees across multiple departments and countries.
• Maintain accurate documentation, ticket updates, and knowledge base articles in accordance with established ITSM processes.
• Collaborate with local and remote coworkers and vendors to design, implement, and continuously improve IT solutions.

Qualifications

• Bachelor's degree in Information Technology, Computer Science, or related field, or equivalent work experience.
• 8-10+ years of experience in systems administration, endpoint management, identity management, or IT operations.
• A broad range of overall IT experience, including Windows, Mac, Databases, Storage, Security, Networking and public clouds.
• Strong hands-on experience with the following or similar:
• Microsoft 365 Administration
• Microsoft Entra ID, including Conditional Access Policies
• Okta
• Endpoint security and device management
• PowerShell (Basic to Intermediate)
• Strong troubleshooting, problem-solving, and analytical skills.
• A track record of taking ownership in issue resolution. No problem is too big or too small.
• Organized and detail orientated.
• Excellent written and verbal communication skills, including clear documentation, ticket updates, and knowledge base contributions.
• Familiarity with ticketing systems and ITSM processes
• Experience working collaboratively with coworkers and vendors, both local and remote, while also being effective working independently.
• You are curious, creative, and innovative and want to continuously improve our processes.
• Previous experience working in a biotech startup or biopharmaceutical.
• Related certifications are a plus
• Ability to explain technical issues clearly to non-technical users
• Patient, customer-focused mindset with a commitment to service quality
• Ability to prioritize tasks and manage multiple issues simultaneously

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $180,250 to $196,751. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.