Onsite Senior Systems Engineer Microsoft Cloud & Infra

BioCryst Pharmaceuticals, Inc.; North Carolina; Hybrid; USD 120,000 - 150,000; Full time

Job summary

BioCryst Pharmaceuticals, Inc. in Durham, NC is seeking a Sr. Systems Engineer to manage Microsoft cloud services (M365, Azure, Exchange, SharePoint, Teams, Entra ID) and provide on‑premises infrastructure support in Durham. This is an in‑office role, five days a week.

You will lead design, implementation, security, governance, and compliance for enterprise cloud platforms, coordinating with MSPs and IT teams to ensure reliable operations and strong cybersecurity posture.

Qualifications

• 7+ years supporting enterprise Microsoft cloud platforms and networking environments.
• Bachelor's degree in IT/CS/Engineering or equivalent experience.
• Strong knowledge of security, governance, compliance in cloud environments.

Responsibilities

• Design, administer, support, and optimize Microsoft enterprise cloud platforms and services.
• Provide operational support and lead evaluation, testing, rollout of new features with emphasis on security and compliance.
• Coordinate with MSPs and vendors to ensure performance and reliability.

Education

Bachelor's degree in Information Technology, Computer Science, Engineering, or related field

Tools

Microsoft 365

Azure

SharePoint Online

Exchange Online

Teams

Purview

Entra ID

Job description

BioCryst Pharmaceuticals, Inc. in Durham, NC is seeking a Sr. Systems Engineer to manage Microsoft cloud services (M365, Azure, Exchange, SharePoint, Teams, Entra ID) and provide on‑premises infrastructure support in Durham. This is an in‑office role, five days a week.

You will lead design, implementation, security, governance, and compliance for enterprise cloud platforms, coordinating with MSPs and IT teams to ensure reliable operations and strong cybersecurity posture.