Sr. Systems Engineer (Onsite Support)

BioCryst Pharmaceuticals; North Carolina; On-site; USD 110,000 - 160,000; Full time

Job summary

BioCryst Pharmaceuticals in Durham, NC seeks a Sr. Systems Engineer to manage Microsoft cloud services (M365, Azure, Exchange Online, SharePoint Online, Teams, Entra ID) and provide on‑premises infrastructure support. The role requires hands‑on leadership within a regulated environment and close MSP collaboration.

The position is office‑based, with five days onsite, and emphasizes security, governance, and compliance across enterprise platforms.

Qualifications

• 7+ years of enterprise Microsoft cloud experience.
• Bachelor's degree in IT/CS/Engineering or equivalent.
• Experience with M365, Azure, Exchange Online, SharePoint Online, Teams, Purview, and Entra ID.
• Strong identity, security, governance, and access management knowledge.
• Experience coordinating with MSPs and third‑party vendors.
• Strong communication and stakeholder engagement skills.
• GxP/SOX experience preferred.
• Microsoft certifications preferred.

Responsibilities

• Design, deploy, and support Microsoft enterprise cloud platforms.
• Lead evaluation and rollout of new features while ensuring availability.
• Architect solutions addressing business and operational needs.
• Administer and support on‑premises infrastructure in Durham.
• Provide onsite infrastructure support five days a week.
• Coordinate with MSPs and vendors for performance and support.
• Ensure security, governance, and compliance controls.
• Create and maintain technical documentation.
• Support meetings and events with reliable tech.
• Other duties as assigned.

Skills

Microsoft 365

Azure

SharePoint Online

Entra ID

Networking

Security & Compliance

Technical leadership

Education

Bachelor's degree in IT/CS/Engineering or equivalent

Tools

Cisco Meraki

Job description

COMPANY:

At BioCryst, we share a deep commitment to improving the lives of people living with hereditary angioedema (HAE) and other rare diseases. We leverage our expertise in structure-guided drug design to develop first-in-class or best-in-class oral small-molecule and injectable protein therapeutics. Our global headquarters is in Durham, North Carolina, we have a regional office in Boston, Massachusetts, and our employees span the globe across sites in multiple countries. We are proud of our culture of engagement and accountability that rewards people for innovative thinking and achievement of key objectives. For more information, please visit our website at www.biocryst.com or follow us on LinkedIn and Instagram.

JOB SUMMARY:

BioCryst is a fast-growing pharmaceutical company seeking an experienced Sr. Systems Engineer to support and manage the company's Microsoft cloud services, including Microsoft 365, Azure, Exchange Online, SharePoint Online, Teams, Entra ID, and related security and compliance technologies. The role will also provide operational support for on-premises infrastructure at the Durham location, including networking, wireless, switching, internet connectivity, and data center technologies. The successful candidate will ensure enterprise systems remain secure, reliable, compliant, and aligned with the company's technology strategy. Please note, this role is NOT remote and you will be required to work in the office 5 days a week.

ESSENTIAL DUTIES & RESPONSIBILITIES:

• Design, administer, support, and optimize Microsoft enterprise cloud platforms and services, including Microsoft 365, Azure, SharePoint Online, Exchange Online, Teams, Purview, and Entra ID. Provide operational support and lead the evaluation, testing, and rollout of new features and service enhancements while ensuring platform availability, performance, reliability, and user adoption.
• Serve as the technical owner for Microsoft enterprise cloud platforms and services, establishing standards, evaluating new capabilities, and ensuring solutions align with business, operational, security, and compliance requirements.
• Architect and deliver solutions that address business and operational needs, serving as the technical lead for the successful implementation of technology initiatives and process improvements while managing multiple priorities and projects.
• Administer and support on-premises infrastructure at the Durham location, including networking, wireless, switching, internet connectivity, firewalls, and related infrastructure systems. Participate in after-hours maintenance and support activities as required.
• Provide onsite infrastructure support five days per week within the Durham office location.
• Partner with the company's managed service providers (MSPs) to monitor, maintain, and troubleshoot cloud and infrastructure services, ensuring performance, availability, and reliability while supporting server, backup, and disaster recovery platforms as needed.
• Partner with Information Security, Compliance, and IT teams to implement, maintain, and optimize Microsoft cloud identity, access, security, governance, and compliance controls while supporting cybersecurity initiatives and remediation efforts.
• Coordinate with Microsoft, service providers, and third-party vendors to troubleshoot issues, evaluate solutions, and ensure service performance and support expectations are met.
• Create and maintain technical documentation, standards, procedures, diagrams, and knowledge articles, and communicate technical information effectively to both technical and non-technical audiences.
• Support onsite company meetings, events, conferences, and business activities within the Durham office, ensuring a reliable and seamless technology experience for employees, guests, and presenters.
• Other duties and projects as assigned.

EXPERIENCE & QUALIFICATIONS:

• 7+ years of experience supporting enterprise Microsoft cloud platforms, infrastructure, and networking environments, preferably within a regulated industry.
• Bachelor's degree in Information Technology, Computer Science, Engineering, or a related field, or an equivalent combination of education and experience.
• Demonstrated expertise designing, implementing, and supporting Microsoft enterprise cloud platforms and services, including Microsoft 365, Azure, Exchange Online, SharePoint Online, Teams, Purview, and Entra ID.
• Strong understanding of Microsoft cloud identity, security, governance, compliance, and access management technologies, including Entra ID, Conditional Access, MFA, Privileged Identity Management (PIM), Microsoft Purview, retention, information protection, and lifecycle management solutions.
• Experience evaluating, testing, deploying, and integrating Microsoft cloud capabilities and service enhancements within a cloud-first enterprise environment.
• Working knowledge of Cisco Meraki, enterprise networking, wireless technologies, firewalls, routing, VPNs, and hybrid cloud infrastructure.
• Working knowledge of server, backup, disaster recovery, monitoring, and infrastructure operations.
• Experience working with managed service providers (MSPs), Microsoft support, and third-party technology vendors.
• Proven ability to serve as a technical lead, driving infrastructure and cloud initiatives from design through implementation while managing multiple priorities and projects.
• Strong analytical, troubleshooting, communication, and problem-solving skills with the ability to effectively engage both technical and non-technical stakeholders.
• Experience supporting GxP, SOX, and other regulated environments preferred.
• Microsoft certifications such as Azure Administrator Associate, Azure Solutions Architect Expert, Microsoft 365 Administrator Expert, or equivalent certifications strongly preferred.

The statements in this position description are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of responsibilities, duties, and skills required of personnel so classified. The manager may assign additional responsibilities and assignments from time to time.

BioCryst is an equal opportunity employer and is committed to providing equal employment opportunities without regard to age, race, religion, sex, sexual orientation, gender identity, national origin, Veterans status, disability and/or other protected class characteristics. Additionally, BioCryst is committed to achieving its business objectives in compliance with all federal, state and local law.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.