Oligonucleotide Process Transfer Lead Foundry Scientist

Eli Lilly and Company; Indianapolis (IN); On-site; USD 131,000 - 211,000; Full time

Benefits offered by this job

401(k) plan

Pension

Vacation benefits

Medical, dental, vision benefits

Well-being benefits

Job summary

Lilly is building the Lilly Medicine Foundry in Indiana, expanding capabilities in oligonucleotide manufacturing. This role leads the PTE function for early-phase cGMP transfers, driving scale-up from development to pilot plant operations across gram-to-kilogram quantities for clinical supply.

The advisor sets technical strategy, mentors scientists, and partners with cross-functional teams to ensure plant readiness and continued innovation in manufacturing processes.

Qualifications

• B.S., M.S., or Ph.D in Chemistry, Biochemistry, Chemical/Biochemical Engineering, or a related discipline.
• B.S. with 20+ years, M.S. with 15+ years, or Ph.D. with 2+ years of oligonucleotide related experience.
• Strong knowledge of oligonucleotide process (synthesis, cleavage, purification) and aseptic processing.

Responsibilities

• Set strategy and direction for oligonucleotide process transfers across programs; scale-up readiness.
• Define scale-up approaches for synthesis and purification from early-phase R&D.
• Serve as technical authority on oligonucleotide unit operations (SP synthesis, chromatography, TFF, lyophilization).
• Collaborate with safety and process engineering to approve high-risk procedures.
• Translate analytical data into strategic recommendations for program leadership.
• Represent process chemistry challenges to senior leadership and cross-functional stakeholders.

Skills

Analytical thinking

Communication

Cross-functional collaboration

Leadership

Education

Chemistry/Biochemistry/Chemical Engineering degree

Tools

HPLC/UPLC

LC-MS

TFF

Lyophilization

Job description

Lilly is building the Lilly Medicine Foundry in Indiana, expanding capabilities in oligonucleotide manufacturing. This role leads the PTE function for early-phase cGMP transfers, driving scale-up from development to pilot plant operations across gram-to-kilogram quantities for clinical supply.

The advisor sets technical strategy, mentors scientists, and partners with cross-functional teams to ensure plant readiness and continued innovation in manufacturing processes.