Oligonucleotide Bioanalysis Scientist — Impactful CRO Role

Synoligo Biotechnologies Inc; North Carolina; On-site; USD 85,000 - 135,000; Full time

Benefits offered by this job

Medical, Dental, Vision and Life Ins.

401k with Company Match

Flexible work schedule

Opportunity to build a department

Job summary

Synoligo Biotechnologies Inc. in Morrisville, NC, is seeking a Bioanalytical Scientist to contribute to oligonucleotide assay development and client projects. You will work within a small team focused on PK/PD, biomarker, and immunogenicity studies for siRNA/ASO therapeutics.

The role requires a PhD in a related field and hands-on expertise with qPCR, ddPCR, immunoassays, and tissue processing. Collaboration with clients, data reporting, and SOP support are key elements of the position.

Qualifications

• Ph.D. in Cell Biology, Molecular Biology, Pharmaceutical Sciences, Biochemistry, or a related field.
• 0–3 years (Scientist), 3–5 years (Sr. Scientist) industry CRO/biotech/pharma experience with achievements.
• Hands-on experience with qPCR, ddPCR, JESS, ELISA, MSD and other immunoassays.
• Experience with animal tissue processing, nucleic acid/protein extraction, and immunoprecipitation.
• Experience with cell-based assays is desirable.
• Knowledge of primer–probe design, oligo thermodynamics, and chemical modifications.
• Experience with LC-MS for oligo quantification is a plus.
• Strong communication, organization, and problem-solving skills.

Responsibilities

• Build internal oligo bioanalytical capabilities and lead client projects on PK/PD, biomarkers, or immunogenicity.
• Design and execute oligo bioanalytical assays (SL-qPCR/ddPCR, hybridization ELISA, RISC, protein assays).
• Establish in-house workflow to process animal tissues and extract DNA, RNA, and protein.
• Analyze and interpret assay data; prepare reports and communicate results to clients.
• Support instrument validation, assay optimization, and SOP development.
• Participate in client meetings as SME and assist project onboarding and progress.

Skills

qPCR

ddPCR

JESS

ELISA

MSD

immunoassays

tissue processing

nucleic acid extraction

protein extraction

immunoprecipitation

cell-based assay

primer-probe design

oligo modifications

LC-MS

Education

PhD in Cell Biology or related field

Tools

qPCR instruments

ddPCR platform

JESS

ELISA reader

LC-MS instrument

Job description

Synoligo Biotechnologies Inc. in Morrisville, NC, is seeking a Bioanalytical Scientist to contribute to oligonucleotide assay development and client projects. You will work within a small team focused on PK/PD, biomarker, and immunogenicity studies for siRNA/ASO therapeutics.

The role requires a PhD in a related field and hands-on expertise with qPCR, ddPCR, immunoassays, and tissue processing. Collaboration with clients, data reporting, and SOP support are key elements of the position.