Oligonucleotide Scientist II

R&D Partners; South San Francisco (CA); On-site; USD 61,000 - 81,000; Full time

Benefits offered by this job

Medical insurance – PPO, HMO & HSA

401k plan

Employee Assistance Program

Long-term disability

Weekly payroll

Online timecard approval

Job summary

R&D Partners in South San Francisco, CA is seeking an Oligonucleotide Scientist II to join the Protein Sciences team. The role focuses on oligonucleotide discovery and synthesis to advance our therapeutics discovery programs and interface with neuroscience, immunology and oncology efforts.

Contract position for 12 months; hands-on lab work and collaboration with chemists, with plans for scaled-up synthesis of lead molecules. Pay range $44.22-$58.93 per hour, plus benefits.

Qualifications

• Hands-on experience in oligonucleotide synthesis using automated oligo synthesizers.
• Purification and characterization using HPLC and mass spectrometry.
• Pharma/biotech R&D experience in RNAi therapeutics preferred.
• Knowledge of nucleic acid therapeutic modalities and modification chemistries.
• Experience in oligonucleotide delivery or bio-conjugation desirable.

Responsibilities

• Work in an oligonucleotide therapeutic drug discovery research lab and interface across therapeutic areas to support discovery strategy.
• Troubleshoot oligonucleotide synthesis and impurity profiling where applicable.
• Collaborate with scientists to maintain lab equipment like oligo synthesizers, HPLC and desalting units.
• Propose and execute nucleic acid chemistry plans; coordinate chemistry and biology data for progression of oligonucleotide compounds.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintain high laboratory productivity to meet timelines for in vitro and in vivo studies.

Skills

Oligonucleotide synthesis

Laboratory troubleshooting

Education

BS/MS in Organic Chemistry or related discipline

Tools

Oligo synthesizers

HPLC

Mass spectrometry

Job description

We are hiring a hiring a Oligonucleotide Scientist II to join our clients Protein Sciences team. We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in

delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology

research and will contribute positively to its developing culture.

This is a 12-month contract position based in South San Francisco, CA.

Responsibilities

• The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
• Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
• Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
• Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.

Qualifications

• BS/MS in Organic Chemistry or related discipline.
• Must have hands‑on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
• The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
• A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred.
• Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.

Pay

• $44.22-$58.93/hr

Why Choose R&D Partners?

As an employee, you have access to a comprehensive benefits package including:

• Medical insurance – PPO, HMO & HSA
• 401k plan
• Employee Assistance Program
• Long-term disability
• Weekly payroll
• Online timecard approval

R&D Partners is a global functional service provider and strategic staffing resource specializing in scientific, clinical research & engineering. We provide job opportunities within major pharmaceutical, biopharmaceutical, biotechnology, and medical device companies.

R&D Partners is an equal-opportunity employer.