Senior Scientist - Oligonucleotide Analytics & Formulation

Deep Genomics; Cambridge (MA); On-site; USD 150,000 - 180,000; Full time

Benefits offered by this job

Stock ownership

Comprehensive benefits (health, vision

Dental coverage

Flexible work environment

Parental leave top-up

Learning and development budget

Job summary

Deep Genomics, based in Cambridge, MA, seeks a scientist to lead analytical characterization and formulation of oligonucleotides for research. You will ensure identity and purity of oligos from CROs and preclinical studies, and lead the build-out of an internal analytics lab.

PhD or MS with strong HPLC/MS expertise, and proven capability in process development for oligonucleotide samples, are required to advance our AI-driven drug discovery initiatives.

Qualifications

• PhD in analytical, pharmaceutical sciences, or bio-organic chemistry with expertise in HPLC and mass spectrometry and 2 years experience; MS in similar fields with +5 years experience.
• Excellent communication skills coupled with good collaboration style.
• Experience in the laboratory techniques for oligonucleotides.
• Experience in designing and implementing new processes for oligonucleotide samples.

Responsibilities

• Maintain efficient workflows for analytical characterization of DG oligos at CROs.
• Develop and implement a plan for installation of an LCMS system for oligonucleotide analysis.
• Act as DG KOL for characterization of oligonucleotides in terms of identity, purity, and stability.
• Develop analytical methods for future LCMS system to characterize research oligonucleotide samples including stability.
• Generate Certificate of Analysis reports from such data.
• Perform formulation processes to provide research samples for in vitro and in vivo experimentation including endotoxin analysis.
• Develop and maintain a sample tracking system for Deep Genomics Cambridge samples.
• Future responsibilities may include bioanalysis of PK samples.

Skills

HPLC

Mass spectrometry

Oligonucleotide lab techniques

Communication

Education

PhD in analytical, pharmaceutical sciences, or bio-organic chemistry

MS in analytical, pharmaceutical sciences, or bio-organic chemistry

Job description

Deep Genomics, based in Cambridge, MA, seeks a scientist to lead analytical characterization and formulation of oligonucleotides for research. You will ensure identity and purity of oligos from CROs and preclinical studies, and lead the build-out of an internal analytics lab.

PhD or MS with strong HPLC/MS expertise, and proven capability in process development for oligonucleotide samples, are required to advance our AI-driven drug discovery initiatives.