Mixed Modality Oligonucleotide Scientist - Tech Transfer Lead

BioSpace; Lebanon (IN); On-site; USD 68,000 - 174,000; Full time

Benefits offered by this job

401(k) plan

Pension

Vacation benefits

Medical, dental, vision benefits

Well-being benefits

Life insurance

Job summary

Lilly Medicine Foundry in Lebanon, Indiana seeks a Mixed Modality (Oligonucleotide) Principal Scientist to drive transfer of oligonucleotide processes from development to pilot plant operations and early‑phase cGMP manufacturing. The role emphasizes plant readiness, scalable methods, and cross‑functional collaboration.

The successful candidate will lead process transfer, document procedures, and mentor junior scientists while contributing to continuous improvement and manufacturing excellence at

Qualifications

• B.S. or M.S. in Chemistry, Biochemistry, Chemical/Biochemical Engineering, or related discipline.
• B.S. with 10+ years or M.S. with 7+ years in oligonucleotide product/process development or related roles.
• Authorized to work in the United States full-time.

Responsibilities

• Transfer oligonucleotide manufacturing processes from development to manufacturing with supervision.
• Oversee transfer, ensure plant fit and troubleshoot issues.
• Scale-up synthesis and purification methods from early-phase labs.
• Document technical transfer plans, SOPs, batch records, and deviation reports.
• Lead investigations, CAPAs, and collaborate with CMC, Product R&D, Manufacturing, and QA.

Skills

Oligonucleotide development

Process transfer

Data analysis

Cross-functional collaboration

Education

B.S. in Chemistry

M.S. in Chemistry

Tools

HPLC/UPLC

LC‑MS

TFF

Preparative chromatography

Job description

Lilly Medicine Foundry in Lebanon, Indiana seeks a Mixed Modality (Oligonucleotide) Principal Scientist to drive transfer of oligonucleotide processes from development to pilot plant operations and early‑phase cGMP manufacturing. The role emphasizes plant readiness, scalable methods, and cross‑functional collaboration.

The successful candidate will lead process transfer, document procedures, and mentor junior scientists while contributing to continuous improvement and manufacturing excellence at