Membrane Protein Scientist (GPCRs) - High-Throughput Expression

Superluminalrx

Boston (MA)

On-site

USD 125,000 - 140,000

Full time

5 days ago
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Benefits offered by this job

Comprehensive benefits package
401(k) match
Massachusetts transportation subsidy
Equity
Unlimited paid time off
Disability and life insurance

Job summary

Superluminal Medicines seeks an innovative Scientist to drive membrane protein production, focusing on GPCR expression, purification, and characterization to support structural biology and biochemistry in drug discovery.

The role emphasizes hands-on lab work with opportunities for scientific leadership, collaboration with pharmacology and medicinal chemistry teams, and shaping the platform's capabilities for hit-to-lead programs.

Qualifications

  • Bachelor's degree with 8+ years, or Master's with 5+ years, or Ph.D. with 2+ years of relevant experience.
  • 2+ years of working experience in biotech or pharmaceutical industry.
  • Experience in molecular biology (cloning, construct design, mutagenesis).
  • Experience in protein stabilization techniques (antibody fragments, fusion partners, mutagenesis).

Responsibilities

  • Design, produce, and optimize membrane protein constructs to improve drug discovery programs.
  • Develop high-throughput expression and purification workflows for Cryo-EM-ready proteins.
  • Collaborate with pharmacology, structural biology, and medicinal chemistry teams to advance programs.
  • Serve as SME on membrane protein expressions within internal and external teams.
  • Document experiments in ELN and present data and strategies to audiences.

Skills

Molecular biology
Protein stabilization
GPCR knowledge
Membrane protein expression

Education

Bachelor's degree in Biochemistry/Molecular Biology/Biophysics or related field
Master's degree with 5+ years of experience
Ph.D. with 2+ years of experience

Tools

FPLC
Cryo-EM
Rosetta
AI/ML design tools

Job description

Superluminal Medicines seeks an innovative Scientist to drive membrane protein production, focusing on GPCR expression, purification, and characterization to support structural biology and biochemistry in drug discovery.

The role emphasizes hands-on lab work with opportunities for scientific leadership, collaboration with pharmacology and medicinal chemistry teams, and shaping the platform's capabilities for hit-to-lead programs.

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