Scientist, Membrane Protein

Superluminal Medicines Inc.; Boston (MA); Vor Ort; USD 125.000 - 140.000; Vollzeit

Benefits dieser Stelle

Medical insurance

Dental insurance

Vision insurance

401(k) match

Massachusetts transportation subsidy

Equity

Unlimited PTO

Disability insurance

Life insurance

Zusammenfassung

Superluminal Medicines in Massachusetts is seeking a highly innovative and experienced Scientist to drive membrane protein production for GPCR targets across drug discovery programs.

This hands-on role focuses on expressing, purifying, and characterizing challenging membrane proteins to support structural biology, biophysics, and biochemistry efforts.

You will collaborate with cross-functional teams, provide scientific leadership, and help shape Superluminal's platform and pipelines.

Qualifikationen

• Bachelor's degree in Biochemistry, Molecular Biology, Biophysics, or related field with 8+ years of experience, a Master's with 5+ years, or a Ph.D. with 2+ years of experience.
• 2+ years of working experience in biotech/pharmaceutical industry.
• Experience in molecular biology (cloning, construct design, mutagenesis).
• Experience in protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).

Aufgaben

• Design, produce, and optimize membrane protein constructs that increase the success rates of small‑molecule therapeutic discovery programs.
• Drive the development of high‑throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and Cryo-EM studies.
• Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit finding to lead optimization.
• Serve as a SME on membrane protein expressions on internal and external project teams; evaluate and implement new technologies.
• Document experiments in ELN, present data and strategies to internal/external audiences.

Kenntnisse

Membrane protein expression expertise

GPCR handling

Molecular biology techniques

Protein purification

Cryo-EM familiarity

Laboratory leadership

Ausbildung

Bachelor's degree in Biochemistry/ Molecular Biology/ Biophysics or related field

Master's degree with 5+ years of experience

PhD with 2+ years of experience

Tools

FPLC (affinity, SEC)

Rosetta

Cryo-EM

Lab automation tools

Jobbeschreibung

About Superluminal Medicines:

Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company's platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation.

About Superluminal Medicines:

Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company's platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation.

Position Summary

We are seeking a highly innovative and experienced Scientist to drive membrane protein production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and biochemistry across drug discovery programs. This role focuses on hands‑on laboratory work and provides opportunities for scientific leadership to shape Superluminal's platform and drug discovery projects.

Key Responsibilities

• Design, produce, and optimize membrane protein constructs that increase the success rates of small‑molecule therapeutic discovery programs.
• Drive the development of high‑throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
• Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit finding to lead optimization.
• Serve as a SME on membrane protein expressions on internal and external project teams; evaluate and implement new technologies.
• Document experiments in ELN, present data and strategies to internal/external audiences.

Required Qualifications

• Bachelor's degree in Biochemistry, Molecular Biology, Biophysics, or a related field with 8+ years of relevant experience, a Master's degree with 5+ years of experience, or a Ph.D. with 2+ years of experience
• 2+ years of working experience in the biotech or pharmaceutical industry.
• Experience in molecular biology (cloning, construct design, mutagenesis).
• Experience in protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).

Preferred Qualifications

• 5+ years of membrane protein expression and purification.
• Experience in protein purification of GPCRs using FPLC (e.g. affinity, SEC).
• Experience with structural biology methods (e.g. data collection and Cryo-EM).
• Experience in laboratory automation in protein sciences & purification.
• Experience in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

Pay Range

$125,000 - $139,902

Benefits:

• Superluminal offers a comprehensive benefits package that fully covers employees' annual deductibles and monthly premiums for medical, dental, and vision insurance.
• The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance.

Equal Opportunity Statement:

Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.