Scientist, Membrane Protein

Superluminal Medicines, Inc.; Boston (MA); Vor Ort; USD 125.000 - 140.000; Vollzeit

Benefits dieser Stelle

Equity

401(k) match

Massachusetts transit subsidy

Unlimited PTO

Healthcare benefits

Zusammenfassung

Superluminal Medicines is seeking a Scientist to drive membrane protein production for GPCRs to support structural biology, biophysics, and drug discovery. This hands-on role requires leadership in protein expression and purification with opportunities to shape the platform.

The candidate should have advanced degrees with substantial experience in membrane protein biochemistry, cloning, and purification, including experience with Cryo-EM workflows.

Qualifikationen

• B.S. in Biochemistry, Molecular Biology, Biophysics or related field with 8+ years experience; or advanced degree with reduced experience.
• 2+ years in biotech/pharma industry and molecular biology experience.
• Experience with cloning, construct design, and mutagenesis.
• Experience with protein stabilization approaches (antibody fragments, fusion partners, mutagenesis).

Aufgaben

• Design, produce and optimize membrane protein constructs for GPCRs.
• Develop high-throughput expression and purification workflows for Cryo-EM readiness.
• Collaborate across pharmacology, structural biology and medicinal chemistry teams.
• Serve as SME on membrane protein expression and evaluate new technologies.
• Document experiments in ELN and present data to teams.

Kenntnisse

Membrane protein expression

GPCR knowledge

Protein purification

Mammalian/insect expression

ELN documentation

Ausbildung

Bachelor's degree with 8+ years

Master's degree with 5+ years

PhD with 2+ years

Tools

FPLC

Cryo-EM

Automation in protein sciences

Rosetta

AI/ML tools

Jobbeschreibung

Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation.

Position Summary

We are seeking a highly innovative and experienced Scientistto drive membrane protein production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and biochemistry across drug discovery programs. This role focuses on hands-on laboratory work and provides opportunities for scientific leadership to shape Superluminal's platform and drug discovery projects.

Key Responsibilities

• Design, produce, and optimize membrane protein constructs that increase the success rates of small-molecule therapeutic discovery programs.
• Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
• Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit finding to lead optimization.
• Serve as a SME on membrane protein expressions on internal and external project teams; evaluate and implement new technologies.
• Document experiments in ELN, present data and strategies to internal/external audiences.

Required Qualifications

• Bachelor’s degree in Biochemistry, Molecular Biology, Biophysics, or a related field with 8+ years of relevant experience, a Master’s degree with 5+ years of experience, or a Ph.D. with 2+ years of experience
• 2+ years of working experience in the biotech or pharmaceutical industry.
• Experience in molecular biology (cloning, construct design, mutagenesis).
• Experience in protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).

Preferred Qualifications

• 5+ years of membrane protein expression and purification.
• Experience in protein purification of GPCRs using FPLC (e.g. affinity, SEC).
• Experience with structural biology methods (e.g. data collection and Cryo-EM).
• Experience in laboratory automation in protein sciences & purification.
• Experience in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

Pay Range

$125,000 - $139,902

The annual base salary range listed above represents the lowest and highest amounts we reasonably and in good faith expect to pay for this position at the time of posting. An individual’s starting base salary within this range will be based on relevant experience, job-related skills, and education relevant to the role. In addition to base salary, this position offers bonus and equity opportunities, as well as benefits.

Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance.

Equal Opportunity Statement:

Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.