Membrane Protein Scientist – GPCR & Cryo-EM Innovator

Superluminal Medicines Inc.; Boston (MA); On-site; USD 125,000 - 140,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) match

Massachusetts transportation subsidy

Equity

Unlimited PTO

Disability insurance

Life insurance

Job summary

Superluminal Medicines in Massachusetts is seeking a highly innovative and experienced Scientist to drive membrane protein production for GPCR targets across drug discovery programs.

This hands-on role focuses on expressing, purifying, and characterizing challenging membrane proteins to support structural biology, biophysics, and biochemistry efforts.

You will collaborate with cross-functional teams, provide scientific leadership, and help shape Superluminal's platform and pipelines.

Qualifications

• Bachelor's degree in Biochemistry, Molecular Biology, Biophysics, or related field with 8+ years of experience, a Master's with 5+ years, or a Ph.D. with 2+ years of experience.
• 2+ years of working experience in biotech/pharmaceutical industry.
• Experience in molecular biology (cloning, construct design, mutagenesis).
• Experience in protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).

Responsibilities

• Design, produce, and optimize membrane protein constructs that increase the success rates of small‑molecule therapeutic discovery programs.
• Drive the development of high‑throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and Cryo-EM studies.
• Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit finding to lead optimization.
• Serve as a SME on membrane protein expressions on internal and external project teams; evaluate and implement new technologies.
• Document experiments in ELN, present data and strategies to internal/external audiences.

Skills

Membrane protein expression expertise

GPCR handling

Molecular biology techniques

Protein purification

Cryo-EM familiarity

Laboratory leadership

Education

Bachelor's degree in Biochemistry/ Molecular Biology/ Biophysics or related field

Master's degree with 5+ years of experience

PhD with 2+ years of experience

Tools

FPLC (affinity, SEC)

Rosetta

Cryo-EM

Lab automation tools

Job description

Superluminal Medicines in Massachusetts is seeking a highly innovative and experienced Scientist to drive membrane protein production for GPCR targets across drug discovery programs.

This hands-on role focuses on expressing, purifying, and characterizing challenging membrane proteins to support structural biology, biophysics, and biochemistry efforts.

You will collaborate with cross-functional teams, provide scientific leadership, and help shape Superluminal's platform and pipelines.