Shift Leader, cGMP Manufacturing Operations

Vertex Pharmaceuticals Inc (US); United States; On-site; USD 98,000 - 147,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Comprehensive benefits

Job summary

Vertex Pharmaceuticals is seeking a Supervisor, Manufacturing Operations to lead the first, second, or third shift in our Drug Product manufacturing facility. You will assign work according to detailed production schedules and oversee on-floor cGMP activities, from equipment setup to cleaning.

In this role you will witness and execute batch records, perform real-time reviews, ensure audit-ready documentation, and maintain compliance with SOPs.

Qualifications

• Bachelor's degree in a scientific/technical/engineering discipline with 6+ years of experience or equivalent.
• Prior supervisory or leadership experience preferred.
• Prior cell therapy and aseptic manufacturing experience preferred.
• Prior POMS MES experience preferred.

Responsibilities

• Lead and supervise daily manufacturing operations.
• Assign work to shift personnel based on detailed production schedules and operational plans.
• Oversee cGMP manufacturing activities including equipment setup, assembly, operation, disassembly, and cleaning.
• Execute and witness batch record instructions to ensure compliant documentation.
• Perform real-time batch record review on the floor.
• Interface with cross-functional teams to support facility operations and maintenance.
• Monitor GMP compliance for personnel and activities within the Drug Product facility.
• Maintain audit-ready facilities through procedures and documentation standards.
• Ensure adherence to SOPs and work instructions; support safe operation.
• Lead Tier 0 and Tier 1 meetings and participate in other duties as needed.

Skills

Leadership

Communication

Organization

GMP Knowledge

Team Coaching

Education

Bachelor's degree in science/engineering

Tools

POMS MES

Job description

Vertex Pharmaceuticals is seeking a Supervisor, Manufacturing Operations to lead the first, second, or third shift in our Drug Product manufacturing facility. You will assign work according to detailed production schedules and oversee on-floor cGMP activities, from equipment setup to cleaning.

In this role you will witness and execute batch records, perform real-time reviews, ensure audit-ready documentation, and maintain compliance with SOPs.