Lead In Vivo Genome Engineering Scientist

St. Jude; Memphis (TN); On-site; USD 60,000 - 105,000; Full time

Job summary

St. Jude Children's Research Hospital seeks a Lead In Vivo Researcher to direct the in vivo components of a translational pipeline for genome engineering therapies addressing hemoglobinopathies and pediatric diseases.

The role requires mastery in stem cell biology, work with humanized models (e.g., NBSGW), and a strong commitment to 3Rs and animal welfare. A graduate degree is preferred and leadership in a high-level research setting is expected.

Qualifications

• Bachelor's degree in a relevant scientific field required.
• Master’s degree or higher is heavily preferred for advanced HSC handling and genome engineering evaluations.

Responsibilities

• Lead and execute complex in vivo studies using humanized and disease-relevant models to evaluate genome engineering outcomes.
• Isolate, characterize, and prepare human Hematopoietic Stem Cells (HSCs) using MACS and flow cytometry.
• Engraft, maintain, and refine advanced humanized models to support translational studies.
• Administer in vivo delivery approaches for experimental therapies with emphasis on welfare and rigor.
• Maintain meticulous documentation of health, engraftment, flow cytometry data, and observations.

Skills

In vivo research

Humanized models

Flow cytometry

MACS

Stem cell handling

Leadership

Education

Bachelor's degree

Master’s degree or higher preferred

Tools

MACS

Multi-color flow cytometry

Job description

St. Jude Children's Research Hospital seeks a Lead In Vivo Researcher to direct the in vivo components of a translational pipeline for genome engineering therapies addressing hemoglobinopathies and pediatric diseases.

The role requires mastery in stem cell biology, work with humanized models (e.g., NBSGW), and a strong commitment to 3Rs and animal welfare. A graduate degree is preferred and leadership in a high-level research setting is expected.