Lead Scientist, In Vivo Base Editing for Pediatric Therapy

St Jude Children's Research Hospital; Memphis (TN); On-site; USD 126,000 - 238,000; Full time

Benefits offered by this job

Relocation assistance

Professional development opportunities

Attend scientific meetings

Job summary

St. Jude Children's Research Hospital invites a Lead Scientist or Senior Scientist to drive development of an in vivo base editing platform for pediatric bone marrow disorders.

You will lead genome editing drug development, oversee genotoxicity assessments, and advance a streamlined platform with in vivo delivery to patients. The Tsai Lab seeks a highly motivated scientist with CRISPR, genomics, and NGS expertise to spearhead IND-enabling studies and early clinical plans over the next several

Qualifications

• PhD in relevant scientific area such as genomics, molecular and cell biology.
• Expertise in genome editing, genomics, next-generation sequencing.
• Excellent communication, organizational, and presentation skills.
• Four or more years of hands-on research laboratory experience working with CRISPR genome editors and NGS library preparation.

Responsibilities

• Design and develop in vivo base editing drug products to treat St. Jude patients with bone marrow failure disorders.
• Characterize the genotoxicity of candidate drug products using state-of-the art genomic assays such as CHANGE-seq-BE and CHANCE-seq, including variant-aware analysis.
• Optimize potency and specificity of a HSC-targeted lipid nanoparticle gene editing approach.
• Co-lead a multi-disciplinary team to test a new streamlined platform approach for in vivo genome editing medicines.

Skills

Genome editing

NGS library prep

CRISPR

Genomics

Communication

Organizational skills

Presentation skills

Education

PhD in relevant scientific area

Tools

CHANGE-seq-BE

CHANCE-seq

Lipid nanoparticles

Job description

St. Jude Children's Research Hospital invites a Lead Scientist or Senior Scientist to drive development of an in vivo base editing platform for pediatric bone marrow disorders.

You will lead genome editing drug development, oversee genotoxicity assessments, and advance a streamlined platform with in vivo delivery to patients. The Tsai Lab seeks a highly motivated scientist with CRISPR, genomics, and NGS expertise to spearhead IND-enabling studies and early clinical plans over the next several