Lead Scientist: In Vivo Base Editing for Pediatric Therapies

St. Jude Children's Research Hospital; Lauderdale Courts (TN); Presencial; USD 126 000 - 238 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Relocation assistance

Professional development

Conference attendance

Resumo da oferta

St. Jude Children's Research Hospital in the United States is seeking a Lead Scientist or Senior Scientist to help lead the development of an in vivo genome editing platform for bone marrow disorders.

You will guide a multi-disciplinary team, advance base editing drug products, and contribute to IND-enabling studies and clinical trials. The role emphasizes leadership, collaboration, and translational work to deliver patient-specific therapies and novel genome editing platforms in pediatric

Qualificações

• PhD in relevant scientific area is required, such as genomics, molecular and cell biology.
• Expertise in genome editing, genomics, next-generation sequencing.
• Excellent communication, organizational, and presentation skills.
• Four or more years of hands-on research laboratory experience working with CRISPR genome editors and NGS library preparation.

Responsabilidades

• Coordinate a team of scientists working to develop a novel gene editing platform.
• Accelerate lead-target discovery, genotoxicity characterization, and cargo optimization.
• Non-clinical pharmacology studies of an HSC-targeted lipid nanoparticle.
• Continuously assess and manage project technical and drug development risks.
• Analyze experimental outcomes and develop high-quality summaries.
• Summarize results and present updates to the broader DRIVE and ARPA-H teams.
• Draft manuscripts and figures for publication in high-impact journals.

Conhecimentos

Genome editing

CRISPR

NGS

Genomics

Formação académica

PhD in genomics/molecular biology

Bachelor's degree

Master's degree

Ferramentas

CHANGE-seq-BE

CHANCE-seq

Descrição da oferta de emprego

St. Jude Children's Research Hospital in the United States is seeking a Lead Scientist or Senior Scientist to help lead the development of an in vivo genome editing platform for bone marrow disorders.

You will guide a multi-disciplinary team, advance base editing drug products, and contribute to IND-enabling studies and clinical trials. The role emphasizes leadership, collaboration, and translational work to deliver patient-specific therapies and novel genome editing platforms in pediatric