Scientist - LC-MS/MS Bioanalytical

Amgen; Thousand Oaks (CA); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Comprehensive employee benefits package

Discretionary annual bonus program

Stock-based long-term incentives

Flexible work models where possible

Job summary

Amgen in Thousand Oaks is seeking a Scientist for LC-MS/MS Bioanalytical methods. This role involves developing robust techniques and performing bioanalysis for clinical studies.

The Scientist will collaborate across teams to ensure compliance with regulations while also partaking in scientific publications and presentations. A PhD or equivalent experience in bioanalytical science is required, and familiarity with diverse sample types is preferred.

Qualifications

• Doctorate degree (PhD) or equivalent.
• 3+ years of LC-MS/MS bioanalytical experience preferred.
• Experience in a lab-based setting.

Responsibilities

• Develop and implement LC-MS/MS bioanalytical methods.
• Conduct bioanalysis of small molecules in clinical samples.
• Ensure bioanalytical data meets regulatory expectations.

Skills

Quantitative mass spectrometry

Bioanalytical experience

Sample preparation techniques

Project management

Education

Doctorate degree (PhD)

Master's degree with 3 years of LC-MS/MS experience

Bachelor's degree with 5 years of LC-MS/MS experience

Tools

LIMS

Triple quadrupole platforms

Job description

Scientist LC-MS/MS Bioanalytical

We are looking for a Scientist to support the design, development, validation, and implementation of robust quantitative LC‑MS/MS bioanalytical methods and experiments for small molecules, and to perform bioanalysis for discovery, GLP preclinical and regulated clinical studies. The role is lab‑based and includes critical review and interpretation of scientific data, report generation, project management, communication of results, automation support, and keeping current with technology development.

The role will involve multidisciplinary collaborations with scientists across research and development and may include contribution to key or critical teams, participation in national scientific meetings, and support of publications, patents or regulatory submissions. Familiarity with peptide and protein quantitation by hybrid LC‑MS/MS methodology and affinity capture techniques is a plus.

Key Responsibilities

• Develop and implement LC‑MS/MS bioanalytical methods with quick turnaround times.
• Conduct small molecule bioanalysis of parent and metabolites in non‑clinical and clinical samples from various matrices (plasma, urine, CSF, tissues).
• Perform biological sample extraction using protein precipitation, SPE, and LLE.
• Generate complete, accurate, and concise documentation using LIMS and electronic laboratory notebook systems.
• Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines.
• Author study reports, standard operating procedures, analytical methods, memos, scientific publications, and other regulatory compliant documents.
• Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings.
• Comply with safety guidelines and site‑specific procedures which include but are not limited to the completion of training on assigned tasks, maintenance of training records, laboratory documentation, and following detailed SOPs and other written procedures.
• Perform general laboratory housekeeping activities and operational support as needed.

Basic Qualifications

• Doctorate degree (PhD)
• PharmD
• MD with relevant post‑doc where applicable
• Master’s degree and 3 years of LC‑MS/MS bioanalytical experience
• Bachelor’s degree and 5 years of LC‑MS/MS bioanalytical experience

Preferred Qualifications

• Prior experience in pharma/biotech strongly desired.
• Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms.
• Demonstrated expertise in working with a variety of sample types (blood, plasma, tissues, urine, cerebrospinal fluid) employing diverse sample preparation techniques (SPE, LLE) to support analysis of small molecules and metabolites by LC‑MS/MS.
• Experience with an array of analytical equipment and technologies that can accelerate bioanalysis including automation and/or micro‑sampling.
• Prior GLP and GCP experience.
• Prior experience in bioanalytical (regulated) assay execution and method transfer to external contract laboratories.
• Understanding of pharmacokinetic and toxicokinetic principles and analysis.
• Willingness to work in a fast‑paced, multi‑project environment with high workload demands, and consistently deliver high‑quality results within established timelines.
• Demonstrated ability to efficiently resolve scientific challenges, prioritize and effectively manage multiple projects.
• Excellent scientific problem‑solving skills.
• Excellent project and time‑management abilities.
• Ability to work collaboratively with internal and external stakeholders.
• Supervisory and mentoring experience in a lab‑based setting.

Benefits

• A comprehensive employee benefits package, including a retirement and savings plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Salary

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on relevant skills, experience, and qualifications.

Equal Opportunity Employer

Amgen is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status or any other basis protected by applicable law.