Senior Quantitative LC-MS Scientist, Protein Bioanalysis
Amgen SA
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Job summary
Amgen is seeking a highly skilled scientist for the Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences group to advance LC-MS based assays. You will develop and apply fit‑for‑purpose methods to quantify target proteins, evaluate target engagement and biomarker kinetics, and support discovery through regulatory submissions.
You will work closely with cross‑functional teams to translate analytical results into mechanistic understanding of drug biology, contributing to Amgen’s mission to
Qualifications
- Doctorate or equivalent with strong LC-MS training in analytical chemistry or related field.
- Proven track record in quantitative bioanalysis in complex matrices.
- Experience with LC-MS method development and biomarker biology.
Responsibilities
- Develop, optimize, and perform quantitative LC-MS assays for target proteins.
- Design bioanalytical strategies to understand drug-target interactions and biomarkers.
- Apply MS-based workflows to plasma, tissue, and in vitro matrices.
- Develop sample prep and LC-MS workflows balancing sensitivity and speed.
- Troubleshoot method development, data quality, and instrument performance.
- Collaborate with cross‑functional teams to interpret data in PK/PD context.
Skills
Education
Tools
Job description
Amgen is seeking a highly skilled scientist for the Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences group to advance LC-MS based assays. You will develop and apply fit‑for‑purpose methods to quantify target proteins, evaluate target engagement and biomarker kinetics, and support discovery through regulatory submissions.
You will work closely with cross‑functional teams to translate analytical results into mechanistic understanding of drug biology, contributing to Amgen’s mission to
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