Senior Quantitative LC-MS Scientist, Protein Bioanalysis

Amgen SA; South San Francisco (CA); On-site; USD 130,000 - 190,000; Full time

Job summary

Amgen is seeking a highly skilled scientist for the Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences group to advance LC-MS based assays. You will develop and apply fit‑for‑purpose methods to quantify target proteins, evaluate target engagement and biomarker kinetics, and support discovery through regulatory submissions.

You will work closely with cross‑functional teams to translate analytical results into mechanistic understanding of drug biology, contributing to Amgen’s mission to

Qualifications

• Doctorate or equivalent with strong LC-MS training in analytical chemistry or related field.
• Proven track record in quantitative bioanalysis in complex matrices.
• Experience with LC-MS method development and biomarker biology.

Responsibilities

• Develop, optimize, and perform quantitative LC-MS assays for target proteins.
• Design bioanalytical strategies to understand drug-target interactions and biomarkers.
• Apply MS-based workflows to plasma, tissue, and in vitro matrices.
• Develop sample prep and LC-MS workflows balancing sensitivity and speed.
• Troubleshoot method development, data quality, and instrument performance.
• Collaborate with cross‑functional teams to interpret data in PK/PD context.

Skills

LC-MS analysis

Bioanalytical expertise

Data interpretation

Cross-functional collaboration

Education

Doctorate in Analytical Chemistry / related field

Master’s degree in related field

Bachelor’s degree in related field

Tools

LC-MS platforms (triple quad, Q-TOF, Orbitrap)

Assay development platforms

Automation workcells (AssayMAP Bravo, Tecan, KingFisher)

Job description

Amgen is seeking a highly skilled scientist for the Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences group to advance LC-MS based assays. You will develop and apply fit‑for‑purpose methods to quantify target proteins, evaluate target engagement and biomarker kinetics, and support discovery through regulatory submissions.

You will work closely with cross‑functional teams to translate analytical results into mechanistic understanding of drug biology, contributing to Amgen’s mission to