Immune Cell Biologist, Inflammation & Target Discovery

Flagship Pioneering; Cambridge (MA); On-site; USD 100,000 - 143,000; Full time

Job summary

Prologue Medicines, founded by Flagship Pioneering, seeks a Scientist in Cellular Immunology and Inflammation to advance therapeutic discovery by designing and running cellular immunology studies that support target validation and mechanism-of-action investigations.

The role is highly hands-on, requiring expertise with human immune cell systems, flow cytometry, and robust assay development, with collaboration across disciplines in a fast-paced discovery environment.

Qualifications

• Hands-on expertise with patient-derived tissues and primary immune cells, including isolation, culture, stimulation and functional characterization.
• Experience with singleplex and multiplex readouts (e.g., MSD, Luminex, ELISA, ELISpot).
• Strong analytical and statistical interpretation skills with relevant tools.

Responsibilities

• Independently design, execute and analyze in vitro and ex vivo cellular immunology experiments for target validation.
• Develop and optimize cell-based assays to evaluate immune activation and inflammatory responses.
• Apply multiparameter flow cytometry to characterize immune populations and responses.
• Isolate and manipulate primary human and animal immune cells using MACS and FACS.
• Design mechanism-of-action studies to validate targets and test hypotheses.
• Use transcriptomics and biomarker readouts to characterize cellular responses.
• Analyze data, troubleshoot assays, and recommend follow-up experiments.
• Collaborate with cross-functional teams to integrate findings into discovery strategies.
• Maintain protocols and ensure rigor and reproducibility.

Skills

PhD in Immunology

Cell biology

Molecular biology

Primary immune cells

Flow cytometry

Cell-based assays

Biomarker readouts

Data analysis

Scientific communication

Independent experimental design

Education

PhD in Immunology, Cell Biology, Molecular Biology

MSc with 6+ years experience

Tools

FlowJo

GraphPad Prism

R

Python

MACS

FACS

Job description

Prologue Medicines, founded by Flagship Pioneering, seeks a Scientist in Cellular Immunology and Inflammation to advance therapeutic discovery by designing and running cellular immunology studies that support target validation and mechanism-of-action investigations.

The role is highly hands-on, requiring expertise with human immune cell systems, flow cytometry, and robust assay development, with collaboration across disciplines in a fast-paced discovery environment.