Immunology Scientist, Early Discovery & Cell Engineering

BeOne Medicines Ltd.; San Carlos (CA); On-site; USD 140,000 - 200,000; Full time

Job summary

BeOne Medicines Ltd. in San Carlos, California, is seeking a highly motivated Scientist to join our early discovery group. You will perform hands-on lab work focused on cell engineering, assay development, and screening workflows to drive novel immune-based therapeutics.

The role requires rigorous execution of projects across multiple initiatives, advancing concepts to scalable assets while collaborating with cross-functional teams and leadership. Onsite work in San Carlos is required.

Qualifications

• Ph.D., MS, or BS in Immunology, Cell Biology, Bioengineering, Molecular Biology.
• Hands-on expertise in primary T-cell biology and iPSC culture.
• Experience with gene editing modalities (CRISPR, base editing) and viral/non-viral cell engineering.
• Proficiency in multi-color flow cytometry and functional immune assays.
• Ability to independently design experiments and interpret data.

Responsibilities

• Design, execute, and analyze experimental workflows to generate high-quality data packages for early discovery.
• Perform molecular biology techniques to support construct design, library assembly, and vector/mRNA preparation.
• Isolate, culture, and engineer primary human immune cells (e.g., T cells) and manage iPSC culture workflows.
• Execute multi-color flow cytometry, cell sorting, magnetic isolation, and quantitative immune-cell functional assays.
• Build, optimize, and run functional screening approaches to evaluate novel targets and constructs.
• Troubleshoot assays, analyze data, and provide insights to guide project strategy.
• Present results to cross-functional teams and discovery leadership.
• Contribute to lab workflows, protocols, and material management at San Carlos site.

Skills

Primary T-cell biology

iPSC culture & differentiation

Gene editing (CRISPR, base editing)

mRNA design/delivery

Functional screening

Flow cytometry & cell sorting

Data analysis

Experimental design

Education

Ph.D., MS, or BS in Immunology, Cell Biology, Bioengineering, Molecular Biology

Tools

CRISPR tools

Lentiviral vectors

qPCR

Cell culture systems

Job description

BeOne Medicines Ltd. in San Carlos, California, is seeking a highly motivated Scientist to join our early discovery group. You will perform hands-on lab work focused on cell engineering, assay development, and screening workflows to drive novel immune-based therapeutics.

The role requires rigorous execution of projects across multiple initiatives, advancing concepts to scalable assets while collaborating with cross-functional teams and leadership. Onsite work in San Carlos is required.