Immune Cell Biologist — In Vitro Systems & Assays

Prellis Biologics, Inc; Berkeley (CA); On-site; USD 120,000 - 180,000; Full time

Job summary

Prellis Biologics seeks a Scientist – Cell Biology & Immunology to develop and optimize our in vitro immune system platform, including lymph node organoid-based technologies, and to advance antibody discovery. The role emphasizes hands-on work with primary immune cells, flow cytometry, and functional assays in a fast-paced startup setting.

The successful candidate will design experiments, analyze data, troubleshoot, and collaborate across disciplines to advance therapeutic candidates and improve

Qualifications

• MS or PhD in Immunology, Cell Biology, Biotechnology, or a related scientific discipline.

Responsibilities

• Design, execute, optimize, and analyze complex cell-based experiments to address key research objectives.
• Develop and implement in vitro immune-cell culture and stimulation strategies.
• Work hands-on in the laboratory, spending 60–80% of time conducting experiments.
• Troubleshoot experimental challenges and improve protocols.
• Isolate, culture, expand, and characterize primary human immune cells using aseptic techniques.
• Work with B cells, T cells, antigen-presenting cells, and other immune-cell populations.
• Contribute to development and optimization of in vitro immune-system platforms.
• Investigate immune-cell activation, proliferation, differentiation, and signaling.
• Design and execute multiparameter flow cytometry experiments for profiling.
• Develop flow cytometry panels and analyze datasets.
• Perform fluorescence-activated cell sorting for antigen-specific populations.
• Utilize beads-based enrichment approaches when appropriate.
• Develop, optimize, and execute functional assays for antibody and TCR discovery.
• Develop assays to evaluate antigen-specific B- and T-cell responses.
• Create ELISA and protein-based assays, plus cell-based screening approaches.
• Contribute to assay development for challenging targets.
• Contribute to antibody discovery programs with in vitro technologies.
• Support identification of antigen-specific B cells and antibody-secreting cells.
• Collaborate with engineers, bioinformaticians, and other teams.

Skills

B and T cell biology

primary immune-cell culture

flow cytometry

cell-based assay development

data analysis

Education

MS/PhD in Immunology or related

Tools

FlowJo

GraphPad Prism

Job description

Prellis Biologics seeks a Scientist – Cell Biology & Immunology to develop and optimize our in vitro immune system platform, including lymph node organoid-based technologies, and to advance antibody discovery. The role emphasizes hands-on work with primary immune cells, flow cytometry, and functional assays in a fast-paced startup setting.

The successful candidate will design experiments, analyze data, troubleshoot, and collaborate across disciplines to advance therapeutic candidates and improve