Immune Cell Biologist, Inflammation

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 100,000 - 143,000; Full time

Job summary

Prologue Medicines in Cambridge, MA is seeking a Scientist, Cellular Immunology and Inflammation to advance therapeutic discovery through designing and running cellular immunology studies that support target validation and mechanism-of-action investigations.

You will work in a collaborative, matrixed environment, applying multiparameter flow cytometry, primary human immune cell cultures, and various readouts to generate high-quality data that informs program decisions.

Qualifications

• PhD in Immunology or related field with strong track record.
• Hands-on with patient-derived tissues and primary immune cells.
• Multiparameter flow cytometry proficiency.
• Development and troubleshooting of cell-based assays.
• Experience with singleplex & multiplex readouts (ELISA, MSD, Luminex).
• Strong data analysis and presentation skills.

Responsibilities

• Design and execute in vitro and ex vivo cellular immunology experiments covering target validation.
• Develop robust cell-based assays for immune activation and inflammatory responses.
• Perform flow cytometry panel design, staining, and data analysis.
• Isolate and culture primary immune cells from human samples.
• Analyze data, troubleshoot assays, and propose follow-up experiments.
• Present findings to cross-functional teams and senior staff.

Skills

Flow cytometry

Primary immune cells

Data analysis

Experiment design

Biomarker readouts

Education

PhD in Immunology

MSc with 6+ years experience in cellular immunology

Tools

FlowJo

GraphPad Prism

R

Python

Luminex

MSD

ELISA

Job description

Prologue Medicines in Cambridge, MA is seeking a Scientist, Cellular Immunology and Inflammation to advance therapeutic discovery through designing and running cellular immunology studies that support target validation and mechanism-of-action investigations.

You will work in a collaborative, matrixed environment, applying multiparameter flow cytometry, primary human immune cell cultures, and various readouts to generate high-quality data that informs program decisions.