gRNA Process Development Scientist

Eurofins USA PSS Insourcing Solutions; Boston (MA); On-site; USD 44,000 - 56,000; Full time

Benefits offered by this job

Comprehensive medical coverage

Dental and vision options

401(k) with company match

Paid vacation and holidays

Yearly bonus & merit-based increases

Job summary

Eurofins USA PSS Insourcing Solutions is seeking a process development scientist to join the gRNA process development team in Boston. You will synthesize, purify, and characterize gRNAs to advance drug substance manufacturing processes.

Responsibilities include carrying out solid-phase synthesis, purification, routine analytics (HPLC/UV-Vis), preparing buffers, compiling data, and maintaining meticulous notebooks in a fast-paced, safety-conscious lab.

Qualifications

• B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experience.
• Experience with oligonucleotide synthesis and purification equipment; gRNA or longmer synthesis/purification is a plus.
• Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangential Flow Filtration (TFF) is required.
• Ability to follow SOPs and maintain electronic lab notebooks (Benchling).
• Commitment to safety, detail orientation, and strong time-management.

Responsibilities

• Execute solid-phase synthesis and purification for process development, scale-up, and transfer.
• Perform routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions per SOPs.
• Compile and present data to team members and stakeholders.
• Maintain an updated lab notebook, order materials, and support equipment troubleshooting.
• Uphold lab safety to the highest standards.

Skills

Oligonucleotide synthesis

Analytical instrumentation

Bench notebook documentation

Safety protocols

Data presentation

Communication

Problem solving

Education

B.S./M.S. in chemistry/biochemistry/chemical engineering

Tools

Akta chromatography systems

Agilent HPLC/UHPLC

NanoDrop

Tangential Flow Filtration (TFF)

Job description

Job Description

We are seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will be contributing to gRNA drug substance process development for programs in clinical development. In this role, the candidate will synthesize, purify, and characterize gRNAs in an effort to develop drug substance manufacturing processes and controls.

• Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.
• Execute routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.
• Compile and present data to team members and key stakeholders
• Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
• Uphold lab safety to the highest level of standards.

Qualifications:
Qualifications

_ Minimum Required Qualifications:_

• B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experience
• Experience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus)
• Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangital Flow Filtration (TFF) is required.
• Ability to follow established SOPs for routine analytical support.
• Experience with good documentation practices and electronic lab notebooks such as Benchling.
• Unwavering commitment to safety protocols and procedures.
• Strong attention to detail, organizational, and time-management skills.
• Effective communication skills for collaborating with team members and conveying technical information clearly.
• Strong problem-solving abilities and critical thinking skills.
• Inquisitive, analytical, laboratory technique familiarity, enthusiasm to learn and contribute in a fast-paced environment.

_ Preferred Qualifications:_

• Background in CRISPR gRNA development.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional Information

The position is full-time, Monday-Friday, 8am-5pm with overtime as needed. Candidates living within a commutable distance of Boston, MA are encouraged to apply.

Excellent full-time benefits include:

• Comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Eligibility for yearly goal-based bonus & merit-based increases
• Compensation: $32.00-$41.00 per hour

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

Compensation:
$32-$32