CRISPR gRNA Process Development Scientist

Eurofins PSS Insourcing Solutions; Boston (KY); On-site; USD 44,000 - 56,000; Full time

Benefits offered by this job

Medical, dental, vision

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Yearly bonus & merit-based increases

Job summary

Eurofins USA PSS Insourcing Solutions is seeking a process development scientist to join the guide-RNA (gRNA) process development team in Boston. You will synthesize, purify, and characterize gRNAs to help develop drug substance manufacturing processes for programs in clinical development.

The role involves executing solid-phase synthesis, purification, routine analytics (HPLC, UV-Vis), preparing buffers per SOPs, documenting results in Benchling, and ensuring safety and quality in a fast-paced

Qualifications

• B.S./M.S. in chemistry, chemical engineering, or biochemistry with at least 2 years of relevant laboratory industry experience.
• Experience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus).
• Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangential Flow Filtration (TFF) is required.
• Ability to follow established SOPs for routine analytical support.
• Experience with good documentation practices and electronic lab notebooks such as Benchling.
• Unwavering commitment to safety protocols and procedures.

Responsibilities

• Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.
• Execute routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.
• Compile and present data to team members and key stakeholders
• Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
• Uphold lab safety to the highest level of standards.

Job description

Eurofins USA PSS Insourcing Solutions is seeking a process development scientist to join the guide-RNA (gRNA) process development team in Boston. You will synthesize, purify, and characterize gRNAs to help develop drug substance manufacturing processes for programs in clinical development.

The role involves executing solid-phase synthesis, purification, routine analytics (HPLC, UV-Vis), preparing buffers per SOPs, documenting results in Benchling, and ensuring safety and quality in a fast-paced