gRNA Process Development Scientist

LabRulez; Boston (MA); Hybrid; USD 44,000 - 56,000; Full time

Benefits offered by this job

Medical, dental, vision benefits

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Bonus potential

Job summary

Eurofins Scientific is seeking a gRNA Process Development Scientist to join the guide-RNA (gRNA) process development team. The candidate will synthesize, purify, and characterize gRNAs to develop drug substance manufacturing processes for programs in clinical development.

The role includes executing synthesis and purification, routine analytics (HPLC/UV-Vis), preparing buffers, and documenting findings. Commutable to Boston, MA with full-time hours and strong safety culture.

Qualifications

• B.S./M.S. in chemistry/biochemistry with 2+ years of laboratory experience.
• Experience with oligonucleotide synthesis and purification equipment (gRNA or longmer work a plus).
• Experience operating analytical equipment such as AKTA chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangential Flow Filtration (TFF).
• Ability to follow SOPs and document thoroughly (Benchling).
• Safety-conscious with strong attention to detail and organization.

Responsibilities

• Execute solid-phase synthesis and purification to support process development and transfer of oligonucleotide drug substance manufacturing.
• Perform routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions following SOPs.
• Compile and present data to team members and stakeholders.
• Maintain lab notebook, order materials, and support equipment troubleshooting.
• Uphold lab safety to the highest standards.

Skills

Attention to detail

Organizational skills

Time management

Communication skills

Problem solving

Analytical thinking

Laboratory techniques

Education

B.S./M.S. in Chemistry/Biochemistry

Tools

AKTA systems

Agilent HPLC

Gel electrophoresis

NanoDrop

Tangential Flow Filtration (TFF)

Job description

Scientific and Research Fellow, Molecular biology, Liquid chromatography

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

In over 35 years, Eurofins has grown from one laboratory in Nantes, France to 61,000 staff across a decentralised and entrepreneurial network of ca. 900 laboratories in 61 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

In 2025, Eurofins generated total revenues of EUR 7.296 billion, and has been among the best performing stocks in Europe over the past 20 years.

gRNA Process Development Scientist

Job Description

We are seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will be contributing to gRNA drug substance process development for programs in clinical development. In this role, the candidate will synthesize, purify, and characterize gRNAs in an effort to develop drug substance manufacturing processes and controls.

• Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.
• Execute routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.
• Compile and present data to team members and key stakeholders
• Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
• Uphold lab safety to the highest level of standards.

Qualifications

Minimum Required Qualifications:

• B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2years of relevant laboratory industry experience
• Experience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus)
• Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangital Flow Filtration (TFF) is required.
• Ability to follow established SOPs for routine analytical support.
• Experience with good documentation practices and electronic lab notebooks such as Benchling.
• Unwavering commitment to safety protocols and procedures.
• Strong attention to detail, organizational, and time-management skills.
• Effective communication skills for collaborating with team members and conveying technical information clearly.
• Strong problem-solving abilities and critical thinking skills.
• Inquisitive, analytical, laboratory technique familiarity, enthusiasm to learn and contribute in a fast-paced environment.

Preferred Qualifications:

• Background in CRISPR gRNA development.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional Information

The position isfull-time, Monday-Friday, 8am-5pmwith overtime as needed.Candidates living within a commutable distance ofBoston, MAare encouraged to apply.

Excellent full-time benefits include:

• Comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Eligibility for yearly goal-based bonus & merit-based increases
• Compensation:$32.00-$41.00 per hour

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.