GPCR Screening Scientist II: Cell-Based Assays & Lead Discovery

Atavistik Bio, Inc.; Cambridge (MA); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) retirement plan

Life insurance

Flexible spending account

Job summary

Atavistik Bio, Inc. is seeking a strategic Scientist II/Senior Scientist with deep expertise in probing GPCR signaling in cell and animal models, to join our R&D group and lead screening campaigns for small molecule drug candidates.

The ideal candidate will have extensive experience creating cell-based assays to measure GPCR readouts and facilitating high-throughput screening in a fast-paced environment. This role is primarily lab-based and will involve CRO-management and cross-functional

Qualifications

• PhD in Biology or a related field.
• 2+ years of experience with cell-based assays to screen GPCR modulators, preferably with small molecules.
• 5+ years of lab experience with immortalized and primary cell lines; skills in cell engineering, CRISPR knockouts, Western blotting, and multi-well plate assays.
• Strong collaborative and communication skills for cross-functional work.

Responsibilities

• Work with the broader drug discovery team to progress compounds from screening to preclinical models.
• Conduct a range of cell-based assays to identify modulators of GPCRs and other targets in the wet lab.
• Collaborate with CROs and academic partners on cell-based screening and patient cell-based assays.
• Design and execute in vivo PK/PD and efficacy models with CROs and academics.
• Communicate data clearly to the team to enable decision making.

Skills

GPCR assays

Cell-based assays

CRISPR knockout

Western blotting

Cell line engineering

High-throughput screening

Education

PhD in Biology

Tools

CRISPR

Western blot

Job description

Atavistik Bio, Inc. is seeking a strategic Scientist II/Senior Scientist with deep expertise in probing GPCR signaling in cell and animal models, to join our R&D group and lead screening campaigns for small molecule drug candidates.

The ideal candidate will have extensive experience creating cell-based assays to measure GPCR readouts and facilitating high-throughput screening in a fast-paced environment. This role is primarily lab-based and will involve CRO-management and cross-functional