Scientist II/Senior Scientist, Biology

Atavistik Bio, Inc.; Cambridge (MA); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) retirement plan

Life insurance

Flexible spending account

Job summary

Atavistik Bio, Inc. is seeking a strategic Scientist II/Senior Scientist with deep expertise in probing GPCR signaling in cell and animal models, to join our R&D group and lead screening campaigns for small molecule drug candidates.

The ideal candidate will have extensive experience creating cell-based assays to measure GPCR readouts and facilitating high-throughput screening in a fast-paced environment. This role is primarily lab-based and will involve CRO-management and cross-functional

Qualifications

• PhD in Biology or a related field.
• 2+ years of experience with cell-based assays to screen GPCR modulators, preferably with small molecules.
• 5+ years of lab experience with immortalized and primary cell lines; skills in cell engineering, CRISPR knockouts, Western blotting, and multi-well plate assays.
• Strong collaborative and communication skills for cross-functional work.

Responsibilities

• Work with the broader drug discovery team to progress compounds from screening to preclinical models.
• Conduct a range of cell-based assays to identify modulators of GPCRs and other targets in the wet lab.
• Collaborate with CROs and academic partners on cell-based screening and patient cell-based assays.
• Design and execute in vivo PK/PD and efficacy models with CROs and academics.
• Communicate data clearly to the team to enable decision making.

Skills

GPCR assays

Cell-based assays

CRISPR knockout

Western blotting

Cell line engineering

High-throughput screening

Education

PhD in Biology

Tools

CRISPR

Western blot

Job description

Company Summary

Atavistik Bio is a privately-held clinical stage biotechnology company accelerating the discovery and development of transformative precision allosteric therapeutics to address serious unmet patient needs. Our proprietary AMPS™ platform allows us to rapidly unlock functional cryptic pockets across a broad range of target classes to accelerate the development of groundbreaking medicines. We have rapidly established an emerging pipeline of allosteric therapeutics with the potential to achieve superior efficacy and tolerability profiles by leveraging the power of allostery.

Company Summary

Atavistik Bio is a privately-held clinical stage biotechnology company accelerating the discovery and development of transformative precision allosteric therapeutics to address serious unmet patient needs. Our proprietary AMPS™ platform allows us to rapidly unlock functional cryptic pockets across a broad range of target classes to accelerate the development of groundbreaking medicines. We have rapidly established an emerging pipeline of allosteric therapeutics with the potential to achieve superior efficacy and tolerability profiles by leveraging the power of allostery.

Position Summary

We are seeking a strategic and dynamic Scientist II/Senior Scientist with deep expertise in probing GPCR signaling in cell and animal models, to join our R&D group and work with an enthusiastic team of highly skilled scientists in a fast-paced environment. Reporting to the SVP, Head of Biology, this individual will be responsible for leading screening campaigns for small molecule drug candidates. The ideal candidate will have extensive experience in developing cell-based assays to measure multiple GPCR-dependent read-outs, high-throughput screening, and the ability to work cross-functionally in a dynamic environment. This position is primarily lab-based, and will also involve CRO-management.

Key Responsibilities

• Work closely with the broader drug discovery scientific team to progress compounds from screening to preclinical animal models
• Perform a wide range of cell-based assays to identify and characterize novel modulators of GPCRs and other therapeutic targets in on-site wet lab.
• Work with CROs and academic partners on a wide-range of drug discovery efforts including cell-based screening and primary patient cell-based assays
• Partner with CROs and academic partners to design and execute in vivo PK/PD and efficacy models
• Clearly communicates the biology, screening data, and other information to team members to enable efficient interpretation and decision making

Required Qualifications

• PhD. in Biology or a related field
• 2+ years of experience working with cell-based assays to screen and identify modulators of GPCRs, preferably with small molecules
• 5+ years of laboratory experience working with immortalized and primary cell lines; strong foundation in standard molecular biology techniques including engineering cell lines, generating CRISPR-based knockout cell lines, western blotting and multi-well plate-based cellular assays
• Strong interpersonal skills and ability to build strong collaborative relationships in a cross-functional environment are a must
• Strong oral and written communication skills, with experience presenting complex scientific data to both internal and external stakeholders

Benefits

Atavistik Bio offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

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Atavistik Bio is an equal opportunity employer. All applicants will be considered for employment without regard to a person's race, color, religion, sex, sexual orientation, gender identity, national origin, veteran status, disability status, or any characteristic protected under applicable law.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.