Functional Proteomics Scientist: Target Discovery & MOA

YOH Services LLC; Seattle (WA); On-site; USD 115,000 - 150,000; Full time

Benefits offered by this job

Medical, Prescription, Dental & Vision

Health Savings Account

Life & Disability Insurance

401K Retirement Savings Plan

Direct Deposit & weekly epayroll

Referral Bonus Programs

Certification and training

Job summary

Yoh seeks a Scientist - Functional Proteomics in Seattle, WA to apply mass spectrometry-based proteomics for target discovery and mechanism-of-action studies. You will design rigorous quantitative experiments and translate complex data into meaningful biological insights for drug-discovery programs.

The ideal candidate combines hands-on proteomics with protein biology knowledge and collaborates across experimental biology, computational science, and drug-discovery teams to advance target

Qualifications

• Ph.D. in proteomics or related field.
• Hands-on MS-based proteomics experience.
• Strong experimental design and data interpretation.
• Ability to collaborate across biology, computational science, and drug-discovery teams.
• Experience generating/profiling proteomics datasets.

Responsibilities

• Design and execute quantitative and functional proteomics experiments supporting target discovery, target validation, compound profiling, and mechanism-of-action research.
• Develop and optimize protein extraction, digestion, enrichment, fractionation, and sample-preparation workflows for mass spectrometry-based studies.
• Design studies evaluating protein abundance, activity, binding, localization, and responses to compound treatment.
• Establish appropriate experimental controls, biological and technical replicates, normalization strategies, and quantitative approaches.
• Develop proteomic strategies for challenging protein classes, including transcription factors, chromatin-associated proteins, and other regulatory proteins.
• Perform mammalian cell culture and cellular compound-treatment experiments as needed.
• Generate, analyze, and interpret quantitative proteomics datasets in collaboration with computational scientists.
• Integrate proteomic findings with genomic, transcriptomic, cellular, and pharmacological datasets to develop biological conclusions.
• Troubleshoot experimental workflows and improve sensitivity, reproducibility, robustness, and throughput.
• Support the development of automated and high-throughput proteomics workflows.
• Present experimental findings, scientific interpretations, and recommendations to cross-functional project teams.
• Contribute to scientific strategy, technical documentation, publications, and presentations.

Skills

Mass spectrometry

Proteomics

Experimental design

Data analysis

Collaboration

Mammalian cell culture

Education

Ph.D. in proteomics or related

Tools

DIA-NN

Spectronaut

Skyline

FragPipe

MaxQuant

Python

R

Job description

Yoh seeks a Scientist - Functional Proteomics in Seattle, WA to apply mass spectrometry-based proteomics for target discovery and mechanism-of-action studies. You will design rigorous quantitative experiments and translate complex data into meaningful biological insights for drug-discovery programs.

The ideal candidate combines hands-on proteomics with protein biology knowledge and collaborates across experimental biology, computational science, and drug-discovery teams to advance target