Scientist – Functional Proteomics

Yoh, A Day & Zimmermann Company; Seattle (WA); On-site; USD 115,000 - 150,000; Full time

Benefits offered by this job

Medical benefits

401K retirement plan

Life & disability insurance

Employee assistance program (EAP)

Job summary

Yoh, a Day & Zimmermann company, seeks a hands-on Scientist – Functional Proteomics in Seattle, WA to drive MS-based proteomics research for drug-discovery programs. You will design quantitative experiments, develop workflows, and translate complex data into actionable biology alongside biology, computation, and chemistry teams.

Ideal candidates hold a PhD and have strong MS-based proteomics expertise, with demonstrated ability to troubleshoot and optimize workflows in a collaborative,

Qualifications

• PhD in proteomics, biochemistry, molecular biology or related field.
• Hands-on mass spectrometry-based proteomics experience.
• Strong experimental design and data interpretation skills.

Responsibilities

• Design and execute quantitative proteomics experiments for target discovery and validation.
• Develop workflows for protein extraction, digestion, enrichment and MS analysis.
• Collaborate with computational scientists to analyse datasets.
• Integrate proteomics with genomic, transcriptomic and pharmacological data.
• Present findings to cross-functional teams and contribute to publications.

Skills

Mass spectrometry

Proteomics

Experiment design

Data interpretation

Collaboration

Education

Ph.D. in proteomics or related

Tools

DIA

Spectronaut

MaxQuant

Skyline

FragPipe

DIA-NN

Python

R

Job description

Scientist – Functional Proteomics

Location: Seattle, WA

Scientist – Functional Proteomics

Location: Seattle, WA

Compensation: $115,000–$150,000 annual base salary

Employment Type: Direct Hire

Work Arrangement: Primarily onsite

Yoh is proactively seeking a Scientist – Functional Proteomics for an anticipated opportunity with a biotechnology company in Seattle, WA.

We are looking for a hands‑on scientist with expertise in mass spectrometry‑based proteomics who can design rigorous quantitative experiments and translate complex proteomic data into meaningful biological insights. This position will support drug‑discovery research involving target identification and validation, compound characterization, and mechanism‑of‑action studies.

The ideal candidate combines strong experimental proteomics capabilities with a deep understanding of protein biology and the ability to collaborate across experimental biology, computational science, and drug‑discovery teams.

What You’ll Do

• Design and execute quantitative and functional proteomics experiments supporting target discovery, target validation, compound profiling, and mechanism‑of‑action research.
• Develop and optimize protein extraction, digestion, enrichment, fractionation, and sample-preparation workflows for mass spectrometry‑based studies.
• Design studies evaluating protein abundance, activity, binding, localization, and responses to compound treatment.
• Establish appropriate experimental controls, biological and technical replicates, normalization strategies, and quantitative approaches.
• Develop proteomic strategies for challenging protein classes, including transcription factors, chromatin‑associated proteins, and other regulatory proteins.
• Perform mammalian cell culture and cellular compound‑treatment experiments as needed.
• Generate, analyze, and interpret quantitative proteomics datasets in collaboration with computational scientists.
• Integrate proteomic findings with genomic, transcriptomic, cellular, and pharmacological datasets to develop biological conclusions.
• Troubleshoot experimental workflows and improve sensitivity, reproducibility, robustness, and throughput.
• Support the development of automated and high‑throughput proteomics workflows.
• Present experimental findings, scientific interpretations, and recommendations to cross‑functional project teams.
• Contribute to scientific strategy, technical documentation, publications, and presentations.

What We’re Looking For

• Ph.D. in proteomics, biochemistry, molecular biology, chemical biology, analytical chemistry, systems biology, or a related scientific discipline preferred.
• Hands‑on experience with mass spectrometry‑based proteomics.
• Strong understanding of quantitative proteomics experimental design, including sample preparation, controls, replicates, and normalization.
• Experience generating, processing, and/or interpreting quantitative proteomics datasets.
• Strong foundation in protein biology and hypothesis‑driven experimental science.
• Demonstrated ability to translate complex datasets into meaningful biological conclusions.
• Ability to independently troubleshoot experimental workflows and make scientifically sound decisions.
• Strong communication skills and experience collaborating across multidisciplinary scientific teams.

Highly Relevant Experience

Experience in one or more of the following areas is strongly preferred:

• Functional proteomics or chemoproteomics
• Compound‑target identification or target‑engagement studies
• Target discovery, target validation, or mechanism‑of‑action research
• Thermal proteome profiling or other protein‑stability approaches
• Affinity‑based or enrichment‑based proteomic methods
• DIA, label‑free, isotopic, or multiplexed quantitative proteomics
• Nuclear, chromatin, or transcription‑factor proteomics
• Mammalian cell culture and compound‑treatment studies
• Drug discovery or pharmacology
• Automated or high‑throughput proteomics workflows
• Proteomics analysis tools such as DIA‑NN, Spectronaut, Skyline, FragPipe, MaxQuant, or similar platforms
• Python and/or R

Additional Information

This position is anticipated to be primarily onsite in Seattle, WA and will work across experimental biology, analytical science, and computational disciplines. This is an anticipated upcoming hiring need, and Yoh is currently building a pipeline of qualified scientists for consideration as the opportunity progresses.

#IND‑SPG

Estimated Min Rate: $115000.00

Estimated Max Rate: $150000.00

What’s In It for You?

Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:

• Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
• Health Savings Account (HSA) (for employees working 20+ hours per week)
• Life & Disability Insurance (for employees working 20+ hours per week)
• MetLife Voluntary Benefits
• Employee Assistance Program (EAP)
• 401K Retirement Savings Plan
• Direct Deposit & weekly epayroll
• Referral Bonus Programs
• Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

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