Scientist – Functional Proteomics

Yoh,-A-Day-; Seattle (WA); On-site; USD 115,000 - 150,000; Full time

Benefits offered by this job

Medical & Vision benefits

HSA

Life & Disability Insurance

401K

Direct Deposit & weekly epayroll

Referral bonuses

Training opportunities

MetLife voluntary benefits

EAP

Job summary

Yoh is seeking a Scientist – Functional Proteomics for an anticipated opportunity in Seattle, WA. You will design quantitative proteomics experiments and translate data into meaningful biological insights to support drug-discovery research.

The role focuses on target identification/validation, compound characterization, and mechanism‑of‑action studies, with collaboration across experimental biology, computational science, and drug-discovery teams.

Qualifications

• Hands-on mass spectrometry proteomics experience.
• Strong experimental design with appropriate controls and replicates.
• Ability to translate complex proteomics data into biology.
• Collaborates across experimental biology, computational science, and drug discovery.

Responsibilities

• Design and execute quantitative and functional proteomics experiments.
• Develop workflows for protein extraction, digestion, enrichment and MS analysis.
• Evaluate protein abundance, activity, localization, and responses to compounds.
• Establish controls, replicates, and normalization strategies.
• Collaborate with computational scientists to analyze datasets.
• Integrate proteomics with genomic and pharmacological data.
• Present findings to cross-functional teams and contribute to publications.

Skills

Mass spectrometry proteomics

Quantitative proteomics

Protein biology

Data analysis (Python/R)

Cross-functional collaboration

Experimental design

Troubleshooting workflows

Education

Ph.D. in proteomics or related

Tools

DIA/Label-free proteomics

MaxQuant

Spectronaut

Skyline

FragPipe

Python

R

Job description

Scientist – Functional Proteomics (BH-400241)

Location Seattle, United States Sector Science & Research Salary $115,000.00 to $150,000.00 per annum

Scientist – Functional Proteomics

Location: Seattle, WA

Compensation: $115,000–$150,000 annual base salary

Employment Type: Direct Hire

Work Arrangement: Primarily onsite

Yoh is proactively seeking a Scientist – Functional Proteomics for an anticipated opportunity with a biotechnology company in Seattle, WA.

We are looking for a hands‑on scientist with expertise in mass spectrometry‑based proteomics who can design rigorous quantitative experiments and translate complex proteomic data into meaningful biological insights. This position will support drug‑discovery research involving target identification and validation, compound characterization, and mechanism‑of‑action studies.

The ideal candidate combines strong experimental proteomics capabilities with a deep understanding of protein biology and the ability to collaborate across experimental biology, computational science, and drug‑discovery teams.

What You’ll Do

• Design and execute quantitative and functional proteomics experiments supporting target discovery, target validation, compound profiling, and mechanism-of-action research.
• Develop and optimize protein extraction, digestion, enrichment, fractionation, and sample-preparation workflows for mass spectrometry-based studies.
• Design studies evaluating protein abundance, activity, binding, localization, and responses to compound treatment.
• Establish appropriate experimental controls, biological and technical replicates, normalization strategies, and quantitative approaches.
• Develop proteomic strategies for challenging protein classes, including transcription factors, chromatin-associated proteins, and other regulatory proteins.
• Perform mammalian cell culture and cellular compound-treatment experiments as needed.
• Generate, analyze, and interpret quantitative proteomics datasets in collaboration with computational scientists.
• Integrate proteomic findings with genomic, transcriptomic, cellular, and pharmacological datasets to develop biological conclusions.
• Troubleshoot experimental workflows and improve sensitivity, reproducibility, robustness, and throughput.
• Support the development of automated and high-throughput proteomics workflows.
• Present experimental findings, scientific interpretations, and recommendations to cross-functional project teams.
• Contribute to scientific strategy, technical documentation, publications, and presentations.

What We’re Looking For

• Ph.D. in proteomics, biochemistry, molecular biology, chemical biology, analytical chemistry, systems biology, or a related scientific discipline preferred.
• Hands‑on experience with mass spectrometry‑based proteomics.
• Strong understanding of quantitative proteomics experimental design, including sample preparation, controls, replicates, and normalization.
• Experience generating, processing, and/or interpreting quantitative proteomics datasets.
• Strong foundation in protein biology and hypothesis‑driven experimental science.
• Demonstrated ability to translate complex datasets into meaningful biological conclusions.
• Ability to independently troubleshoot experimental workflows and make scientifically sound decisions.
• Strong communication skills and experience collaborating across multidisciplinary scientific teams.

Highly Relevant Experience

• Functional proteomics or chemoproteomics
• Compound‑target identification or target‑engagement studies
• Target discovery, target validation, or mechanism‑of‑action research
• Thermal proteome profiling or other protein‑stability approaches
• Affinity‑based or enrichment‑based proteomic methods
• DIA, label‑free, isotopic, or multiplexed quantitative proteomics
• Nuclear, chromatin, or transcription‑factor proteomics
• Mammalian cell culture and compound‑treatment studies
• Drug discovery or pharmacology
• Automated or high‑throughput proteomics workflows
• Proteomics analysis tools such as DIA‑NN, Spectronaut, Skyline, FragPipe, MaxQuant, or similar platforms
• Python and/or R

Additional Information

This position is anticipated to be primarily onsite in Seattle, WA and will work across experimental biology, analytical science, and computational disciplines. This is an anticipated upcoming hiring need, and Yoh is currently building a pipeline of qualified scientists for consideration as the opportunity progresses.

#IND-SPG

Estimated Min Rate: $115000.00

Estimated Max Rate: $150000.00

What’s In It for You?

• Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
• Health Savings Account (HSA) (for employees working 20+ hours per week)
• Life & Disability Insurance (for employees working 20+ hours per week)
• MetLife Voluntary Benefits
• Employee Assistance Program (EAP)
• 401K Retirement Savings Plan
• Direct Deposit & weekly epayroll
• Referral Bonus Programs
• Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

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For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

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