Downstream Process Scale-Up Scientist – AAV

Sanofi Group; Waltham (MA); On-site; USD 86,000 - 124,000; Full time

Benefits offered by this job

Parental leave

Health benefits

International opportunities

Job summary

Sanofi Group is seeking a Scientist in Waltham, MA to lead execution and scale‑up of downstream purification from pilot to large-scale production, partnering with CMC teams on manufacturing campaigns.

The role emphasizes hands‑on chromatography and Tangential Flow Filtration (TFF), with strong experience in process tech transfers, batch records, and data analyses to improve yield and cycle times.

Qualifications

• Master’s degree in chemical or biochemical engineering with a minimum of 2 years of relevant experience, or a bachelor’s degree with a minimum of 4 years of relevant experience.
• Hands‑on experience with Chromatography and Tangential Flow Filtration (TFF) in pilot- and large-scale DSP operations.
• Experience with process technology transfers and drafting batch records and SOPs; ability to contribute to technical reports and data analyses.

Responsibilities

• Lead the execution and scale‑up of downstream purification manufacturing from 50-L pilot through 2000-L scale.
• Author and revise SOPs, batch records, and batch reports for pilot and large-scale operations.
• Perform data analyses to support DSP manufacturing and contribute to technical reports and presentations.
• Troubleshoot manufacturing issues and communicate findings to cross-functional teams.
• Support digital transformation initiatives (e.g., electronic batch records) and continuous improvement in GMU CMC.

Skills

Chromatography

Tangential Flow Filtration

Pilot- and large-scale DSP

Data analysis

Downtime reduction

Education

Master’s degree in chemical or biochemical engineering

Bachelor’s degree with minimum 4 years relevant experience

Tools

Chromatography systems

TFF equipment

Job description

Sanofi Group is seeking a Scientist in Waltham, MA to lead execution and scale‑up of downstream purification from pilot to large-scale production, partnering with CMC teams on manufacturing campaigns.

The role emphasizes hands‑on chromatography and Tangential Flow Filtration (TFF), with strong experience in process tech transfers, batch records, and data analyses to improve yield and cycle times.