Downstream Process Scale-Up Scientist

Sanofi; Waltham (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Sanofi’s Genomic Medicine Unit (GMU) CMC is seeking a Scientist to lead downstream purification initiatives for AAV and related viral vectors. You’ll drive scale-up from pilot to 2,000-L production, collaborate with CMC teams, and contribute to process development and tech transfer activities.

The role requires hands-on purification experience, strong chromatographic skills, and a proactive approach to continuous improvement in a fast-paced biopharma setting.

Qualifications

• Master’s degree with 2+ years’ experience or Bachelor’s with 4+ years’ experience.
• Hands-on experience with pilot- and large-scale downstream purification.
• Experience with process tech transfers and risk assessments.

Responsibilities

• Lead scale-up of downstream purification from pilot to large scale.
• Author and revise SOPs, batch records, and batch reports.
• Perform data analyses and contribute to technical reports.
• Troubleshoot manufacturing issues and communicate findings.
• Maintain critical equipment and pursue new technology opportunities.
• Support digital transformation and continuous improvement in GMU CMC.
• Mentor junior staff and foster teamwork in purification sciences.

Skills

DSP manufacturing

Chromatography

Tangential Flow Filtration

Process scale-up

Data analysis

Education

Master’s degree in chemical/biochemical engineering

Bachelor’s degree in chemical/biochemical engineering or related field

Tools

Chromatography equipment

TFF systems

AAV purification workflows

Job description

Sanofi’s Genomic Medicine Unit (GMU) CMC is seeking a Scientist to lead downstream purification initiatives for AAV and related viral vectors. You’ll drive scale-up from pilot to 2,000-L production, collaborate with CMC teams, and contribute to process development and tech transfer activities.

The role requires hands-on purification experience, strong chromatographic skills, and a proactive approach to continuous improvement in a fast-paced biopharma setting.