Principal Scientist – AAV Downstream Process Lead

Novartis AG; San Diego (CA); On-site; USD 109,000 - 222,000; Full time

Benefits offered by this job

Health benefits

401(k) with company match

Generous time off package

Job summary

Novartis AG seeks a Principal Scientist I/II with extensive experience in AAV gene therapy manufacturing to lead downstream purification development. The role includes driving developability of lead candidates, collaborating across functions, and transferring process knowledge to R&D for clinical advancement.

The position emphasizes independent problem solving, strong communication, and management of a 3-5 person team in a fast-paced, matrix environment, onsite in San Diego, CA.

Qualifications

• PhD in bioprocessing, biochemical engineering or related field with 3+ years of process development experience.
• Experience in people management and team leadership.
• Knowledge of downstream purification including affinity and ion-exchange chromatography and AKTA systems.

Responsibilities

• Lead and manage a 3-5 person downstream process team with training and SME support.
• Coordinate activities with upstream process and analytical teams.
• Develop strategies with Disease Areas and collaborate across functions for early drug discovery.
• Transfer manufacturing process knowledge to R&D and advance programs to clinic.
• Develop innovative, cost-effective downstream processes for next-gen AAV.
• Manage multiple projects to ensure timely delivery.
• Prepare reports following defined documentation practices.
• Perform other duties as assigned.

Skills

People management

Downstream purification

Chromatography knowledge

Bioprocessing expertise

Cross-functional collaboration

Education

PhD in bioprocessing

Tools

AKTA purification systems

Job description

Novartis AG seeks a Principal Scientist I/II with extensive experience in AAV gene therapy manufacturing to lead downstream purification development. The role includes driving developability of lead candidates, collaborating across functions, and transferring process knowledge to R&D for clinical advancement.

The position emphasizes independent problem solving, strong communication, and management of a 3-5 person team in a fast-paced, matrix environment, onsite in San Diego, CA.