DMPK Scientist – PK/PD Modeling & ADME Strategy

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 110,000 - 166,000; Full time

Benefits offered by this job

Medical benefits

401(k) with company match

Paid time off

Job summary

Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions.

The role demands expertise in non-compartmental and compartmental analysis, PBPK, and systems pharmacology, with strong communication and teamwork within a fast-paced environment.

Qualifications

• Ph.D. in pharmaceutical sciences, pharmacology, chemical or biomedical engineering or related quantitative discipline with 0+ years of relevant experience; or exceptional non-PhD with 5+ years (Masters) or 10+ years (Bachelors) in DMPK or quantitative pharmacology.
• Strong foundation in quantitative pharmacology and PK/PD modeling, with hands-on experience in non-compartmental and compartmental data analysis.
• Exposure to PBPK, population PK, or systems/mechanistic pharmacology modeling is a strong plus.
• Proficiency with modeling, simulation, and programming tools (Phoenix WinNonlin, Monolix, R).
• Solid understanding of ADME principles and the drug discovery and development process; knowledge of oligonucleotide therapeutics (siRNA/ASO) or other novel modalities is a plus.
• Demonstrates problem solving ability and adaptability, in and out of comfort zone.
• Detail-oriented with organizational skills and ability to handle multiple projects in a fast-paced, team environment.

Responsibilities

• Support DMPK strategy across drug discovery and development by designing, executing, and interpreting in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities.
• Apply quantitative pharmacology approaches including non-compartmental analysis, compartmental PK/PD, PBPK, and mechanistic/systems modeling to characterize drug disposition and exposure–response.
• Integrate PK, PD, and biomarker data to inform candidate selection, human dose projection, and first-in-human dose predictions.
• Build, qualify, and document models and simulations using Phoenix WinNonlin, Monolix, R and related tools.
• Contribute to preclinical and translational study designs to support progression from discovery through clinical development.
• Collaborate with cross-functional teams to analyze data and communicate quantitative pharmacology insights.
• Prepare analyses, reports, and presentations; contribute to regulatory submissions as needed.
• Complete projects in a timely and high-quality manner while maintaining scientific rigor.

Skills

Quantitative pharmacology

PK/PD modeling

Pharmacokinetic data analysis

Education

Ph.D. in pharmaceutical sciences

Master's degree with 5+ years in industry

Bachelor's degree with 10+ years in industry

Tools

Phoenix WinNonlin

Monolix

R

Job description

Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions.

The role demands expertise in non-compartmental and compartmental analysis, PBPK, and systems pharmacology, with strong communication and teamwork within a fast-paced environment.