Scientist, DMPK

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 110,000 - 166,000; Full time

Benefits offered by this job

Medical benefits

401(k) with company match

Paid time off

Job summary

Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions.

The role demands expertise in non-compartmental and compartmental analysis, PBPK, and systems pharmacology, with strong communication and teamwork within a fast-paced environment.

Qualifications

• Ph.D. in pharmaceutical sciences, pharmacology, chemical or biomedical engineering or related quantitative discipline with 0+ years of relevant experience; or exceptional non-PhD with 5+ years (Masters) or 10+ years (Bachelors) in DMPK or quantitative pharmacology.
• Strong foundation in quantitative pharmacology and PK/PD modeling, with hands-on experience in non-compartmental and compartmental data analysis.
• Exposure to PBPK, population PK, or systems/mechanistic pharmacology modeling is a strong plus.
• Proficiency with modeling, simulation, and programming tools (Phoenix WinNonlin, Monolix, R).
• Solid understanding of ADME principles and the drug discovery and development process; knowledge of oligonucleotide therapeutics (siRNA/ASO) or other novel modalities is a plus.
• Demonstrates problem solving ability and adaptability, in and out of comfort zone.
• Detail-oriented with organizational skills and ability to handle multiple projects in a fast-paced, team environment.

Responsibilities

• Support DMPK strategy across drug discovery and development by designing, executing, and interpreting in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities.
• Apply quantitative pharmacology approaches including non-compartmental analysis, compartmental PK/PD, PBPK, and mechanistic/systems modeling to characterize drug disposition and exposure–response.
• Integrate PK, PD, and biomarker data to inform candidate selection, human dose projection, and first-in-human dose predictions.
• Build, qualify, and document models and simulations using Phoenix WinNonlin, Monolix, R and related tools.
• Contribute to preclinical and translational study designs to support progression from discovery through clinical development.
• Collaborate with cross-functional teams to analyze data and communicate quantitative pharmacology insights.
• Prepare analyses, reports, and presentations; contribute to regulatory submissions as needed.
• Complete projects in a timely and high-quality manner while maintaining scientific rigor.

Skills

Quantitative pharmacology

PK/PD modeling

Pharmacokinetic data analysis

Education

Ph.D. in pharmaceutical sciences

Master's degree with 5+ years in industry

Bachelor's degree with 10+ years in industry

Tools

Phoenix WinNonlin

Monolix

R

Job description

Overview

The mission ofDMPKis to enable efficient and successful drug discovery and development of siRNA and other therapeutic candidates by characterizing and interpreting ADME (absorption, distribution, metabolism, and excretion) and PK/PD (pharmacokinetics/pharmacodynamics) relationships through quantitative pharmacology and modeling, consequently guiding candidate selection, human dose projection, and successful regulatory filings and interactions.

The ideal candidate will have a strong background in quantitative pharmacology, PK/PD modeling, and pharmacokinetic data analysis, a solid understanding of ADME and drug disposition, and exceptional problem-solving and communication skills to successfully collaborate with multiple project teams in a matrixed and fast-paced environment. This is an exciting opportunity to join a vibrant team and interact with highly motivated scientists across a broad array of disciplinary expertise areas.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Support DMPK strategy across drug discovery and development by designing, executing, and interpreting in vitro and in vivo ADME and PK/PD studies for siRNA and other therapeutic modalities.


• Apply quantitative pharmacology approaches-including non-compartmental analysis, compartmental PK/PD, PBPK, and mechanistic/systems modeling-to characterize drug disposition and exposure-response relationships.


• Integrate PK, PD, and biomarker data to inform candidate selection, human dose projection, and first-in-human dose predictions.


• Build, qualify, and clearly document models and simulations using tools such as Phoenix WinNonlin, Monolix, R, and other equivalent tools.


• Contribute to the design of preclinical and translational studies that support progression of candidates from discovery through clinical development.


• Collaborate with cross-functional project teams (bioanalysis, chemistry, biology, toxicology, and clinical pharmacology) to analyze data and communicate quantitative pharmacology insights.


• Prepare clear, well-documented analyses, reports, and presentations, and contribute to regulatory submissions as needed.


• Complete projects in a timely and clearly documented manner while maintaining high scientific and data-quality standards.


• Stay current with emerging modeling methodologies and scientific literature to continuously strengthen the team's quantitative capabilities.

Qualifications

• Ph.D. in pharmaceutical sciences, pharmacology, chemical or biomedical engineering, or a related quantitative discipline with 0+ years of relevant experience; or exceptional non-PhD (Masters degree with 5+ years, or Bachelors degree with 10+ years of relevant industry experience in DMPK or quantitative pharmacology.


• Strong foundation in quantitative pharmacology and PK/PD modeling, with hands-on experience in non-compartmental and compartmental data analysis.


• Exposure to PBPK, population PK, or systems/mechanistic pharmacology modeling is a strong plus.


• Proficiency with modeling, simulation, and programming tools (e.g., Phoenix WinNonlin, Monolix, R).


• Solid understanding of ADME principles and the drug discovery and development process; knowledge of oligonucleotide therapeutics (e.g., siRNA, ASO) or other novel modalities is a plus.


• Demonstrates strong problem solving ability and adaptability, in and out of their comfort zone


• Detail-oriented with exceptional organizational skills, and the ability to handle multiple projects, and thrive in a fast-paced, team-oriented environment


• Has strong interpersonal skills to enable collaboration with cross-functional teams.

Possesses excellent verbal and written communication skills.

#LI-JR1

U.S. Pay Range

$110,400.00 - $165,600.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.