Lead DMPK Scientist, PK/PD & Translational Medicine

Alnylam Pharmaceuticals; Cambridge (MA); On-site; USD 147,000 - 221,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) with company match

Paid time off

Job summary

Alnylam Pharmaceuticals (Cambridge, MA) seeks a Principal Scientist to lead DMPK strategies across discovery to clinical development. You will drive PK/PD translational pharmacology, design/interpret ADME studies, and collaborate with cross-functional teams to inform program decisions.

You will mentor junior scientists, prepare regulatory submission content, and contribute to strategic discussions on development plans.

Qualifications

• Ph.D. in pharmacokinetics, pharmaceutical sciences, pharmacology, biomedical engineering, or related discipline.

Responsibilities

• Develop and implement DMPK strategies to support discovery, selection, translational research and clinical development.
• Design, execute, interpret, and communicate DMPK studies covering ADME, PK/PD relationships and translational pharmacology.
• Collaborate with Research scientists to optimize tissue delivery, pharmacology, and candidate selection.
• Partner with Toxicology, Clinical Pharmacology, Bioanalytical Sciences, Regulatory Affairs, and Project Leadership to integrate data for development decisions.
• Apply quantitative approaches, including modeling and simulation, to support dose prediction and translation.
• Represent DMPK on cross-functional teams and contribute to program governance discussions.
• Lead or contribute to preparing DMPK reports and regulatory submission content (CTA, IND, NDA).
• Provide mentorship and build DMPK capabilities across the organization.

Skills

PK/PD principles

ADME understanding

Regulatory submissions

Quantitative modeling

Multidisciplinary collaboration

Scientific leadership

Data integration

Communication skills

Education

Ph.D. in pharmacokinetics/pharmaceutical sciences

Job description

Alnylam Pharmaceuticals (Cambridge, MA) seeks a Principal Scientist to lead DMPK strategies across discovery to clinical development. You will drive PK/PD translational pharmacology, design/interpret ADME studies, and collaborate with cross-functional teams to inform program decisions.

You will mentor junior scientists, prepare regulatory submission content, and contribute to strategic discussions on development plans.