Director, Nonclinical Development - ADME/DMPK

Scorpion Therapeutics; Boston (MA); Hybrid; USD 180,000 - 320,000; Full time

Job summary

Scorpion Therapeutics is seeking a Lead in nonclinical ADME/DMPK to guide development for small molecules and peptides from discovery through late-stage trials. Hybrid work setup with some travel, based in Boston area.

The role requires a PhD and 10+ years in industry, with demonstrated leadership in PK/PD, DMPK, and regulatory submissions. You will drive cross-functional collaboration and strategic decision-making across programs.

Qualifications

• PhD required in pharmacokinetics, pharmacology, or related field.
• 10+ years industry experience in small molecule drug development, nonclinical DMPK, and modeling.
• Strong regulatory knowledge and excellent communication for internal/external engagement.

Responsibilities

• Develop and oversee integrated DMPK strategies from discovery to NDA/submission.
• Lead PK/PD analyses and modeling (PBPK, MIDD) to inform dose selection.
• Provide scientific leadership in nonclinical pharmacokinetics, metabolism, and DDI assessments.

Education

PhD in Pharmacokinetics, Pharmacology, or related field

Tools

PBPK platform

Job description

Role

Lead strategic nonclinical ADME/DMPK development for small molecule and peptide therapeutics from discovery through late-stage clinical trials and registration.

Responsibilities

Develop and oversee integrated DMPK strategies supporting IND-enabling to Phase 3, drive cross-functional collaboration, lead PK/PD and modeling analyses (PBPK, MIDD), inform first-in-human dose selection, and contribute to regulatory submissions and health authority interactions. Serve as the scientific authority in nonclinical pharmacokinetics, metabolism, and drug-drug interaction assessments, providing expert guidance and translating complex data into strategic decisions.

Requirements

PhD in Pharmacokinetics, Pharmacology, or related field; 10+ years in industry with proven experience in small molecule drug development, nonclinical DMPK, and modeling approaches; strong regulatory knowledge; excellent communication skills for internal and external engagement.

Preferred

Experience supporting Phase 2/3 and NDA submissions; expertise in peptide or novel modalities; advanced PBPK platform skills; global regulatory exposure; biotech startup experience.

High-Value

Expertise in ADME, DMPK, translational science, modeling (PK/PD, PBPK), regulatory strategy, and cross-functional leadership.

Work setup

Hybrid in Boston, Massachusetts; some travel expected.