Director/Sr. Director Clinical Pharmacology

BridgeBio Inc.; United States; On-site; USD 180,000 - 250,000; Full time

Benefits offered by this job

Remote work

Quarterly SF site visits

Job summary

Scorpion Therapeutics seeks a Director/Senior Director, Clinical Pharmacology to lead pediatric pharmacometrics for rare diseases. You will develop population PK, PK/PD, exposure–response, and PBPK models to guide dose selection across Phase 2/3 trials and inform study design.

The role requires a Ph.D. or Pharm.D. with 10+ years in biotech/pharma and strong regulatory and leadership abilities. Remote US-based with quarterly site visits in San Francisco.

Qualifications

• Ph.D. or Pharm.D. with 10+ years in biotech/pharma.
• Expertise in population PK, PK/PD, exposure–response, and PBPK modeling.
• Strong analytical, communication, and leadership skills.

Responsibilities

• Design population PK, PK/PD, exposure–response, and PBPK models to inform dose selection and study design across Phase 2 and 3 trials.
• Author regulatory documents and support regulatory interactions.
• Oversee clinical pharmacology studies and CROs and translate data into insights for teams and stakeholders.

Skills

Pharmacometric modeling

Pediatric drug development

Leadership

Regulatory interactions

Education

Ph.D. or Pharm.D.

Tools

NONMEM

Monolix

R

Job description

Role

Role: Director/Senior Director, Clinical Pharmacology, leading pharmacometric strategies in pediatric drug development for rare diseases.

Responsibilities

Responsibilities include designing and applying population PK, PK/PD, exposure–response, and PBPK models to inform dose selection, study design, and efficacy/safety optimization across Phase 2 and 3 trials; authoring regulatory documents; supporting regulatory interactions; overseeing clinical pharmacology studies and CROs; and translating complex data into actionable insights for internal teams and external stakeholders.

Requirements

Requirements: Ph.D. or Pharm.D. with 10+ years in biotech/pharma; expertise in modeling and simulation tools (e.g., NONMEM, Monolix, R); strong understanding of regulatory expectations (FDA, EMA); proven pediatric drug development experience preferred; excellent analytical, communication, and leadership skills.

HighValue

HighValue: pediatric populations (0–18 years), rare disease focus, model-informed drug development (MIDD), global regulatory engagement, remote work with quarterly site visits in San Francisco.

Work Setup

Work setup: remote US-based role with occasional in-person meetings.