Clinical Pharmacology Lead (Manager)

Scorpion Therapeutics; Pennsylvania; Hybrid; USD 180,000 - 240,000; Full time

Job summary

Scorpion Therapeutics seeks a Clinical Pharmacology Lead to advance model-informed drug development (MIDD) for its Internal Medicine portfolio. The role emphasizes dosing strategy, PK/PD integration, and study design within a hybrid work environment.

The incumbent will serve as the clinical pharmacology representative on cross-functional teams, design comprehensive pharmacology plans, and contribute to regulatory submissions and documentation, shaping development decisions across early through

Qualifications

• MD/PhD or PharmD with 0+ years (MD/PhD) or 2+ years (PharmD) in pharmacokinetics, pharmacometrics, or related fields.

Responsibilities

• Act as clinical pharmacology representative on cross-functional teams, design and oversee clinical pharmacology plans, integrate PK/PD data with patient and disease characteristics, and contribute to regulatory documentation.

Skills

PK/PD modeling

pharmacokinetics

pharmacodynamics

pharmacometrics

clinical trial simulation

Education

MD/PhD

PharmD

Tools

NONMEM

R

Job description

Role: Clinical Pharmacology Lead supporting Pfizer’s Internal Medicine portfolio, focusing on model-informed drug development (MIDD) to inform dosing and study design.

Responsibilities

• act as clinical pharmacology representative on cross-functional teams, design and oversee clinical pharmacology plans, integrate PK/PD data with patient and disease characteristics, and contribute to regulatory documentation.

Requirements

• MD/PhD or PharmD with 0+ years (MD/PhD) or 2+ years (PharmD) in pharmacokinetics, pharmacometrics, or related fields; expertise in PK/PD modeling, systems pharmacology, and clinical trial simulation (using NONMEM, R, etc.); strong communication and collaboration skills.

High-Value: supports early to late-phase (FIH through Phase 3) drug development in internal medicine; regulatory engagement; hybrid work environment, requiring onsite presence ~2.5 days/week; global team interaction. The role emphasizes innovative modeling, dose optimization, and strategic input for clinical development plans within Pfizer’s MIDD framework.