Senior Director, Clinical Pharmacology

Scorpion Therapeutics; Boston (MA); Hybrid; USD 210,000 - 300,000; Full time

Benefits offered by this job

Hybrid work in Boston

Travel opportunities

Job summary

Scorpion Therapeutics in Boston, MA, is seeking a Senior Director of Clinical Pharmacology to shape and execute clinical pharmacology strategies across early- and late-phase programs, including small molecules and peptides.

You will design and interpret PK/PD studies, support dose selection, lead regulatory submissions, manage CROs, and collaborate with cross-functional teams to advance rare neuroendocrine disease programs.

Qualifications

• Ph.D. or Pharm.D. in Clinical Pharmacology or related field.
• 12+ years of industry experience with global regulatory submissions.
• Proficiency in PK/PD modeling and exposure–response concepts.
• Experience with rare diseases, combination therapy, pediatric development preferred.

Responsibilities

• Design, implement, and interpret pharmacology studies (Ph 1-3).
• Support dose selection, exposure–response modeling, and combination therapies.
• Lead regulatory submissions and interactions with authorities.
• Oversee CROs and pharmacometric vendors.
• Collaborate with cross-functional teams in clinical development, regulatory affairs, biostatistics, and non-clinical sciences.

Skills

12+ years industry experience

PK/PD modeling & exposure-response

Regulatory submissions experience

Cross-functional collaboration

Small molecule & peptide pharmacology

Education

Ph.D./Pharm.D. in Clinical Pharmacology or related field

Tools

NONMEM

Phoenix WinNonlin

Job description

Role: Senior Director, Clinical Pharmacology at a biopharma focused on rare neuroendocrine diseases, responsible for shaping and executing clinical pharmacology strategies across early and late-phase programs involving small molecules and peptides.

Responsibilities

• Design, implement, and interpret pharmacology studies (Ph 1-3)
• Support dose selection, exposure-response modeling, and combination therapies
• Lead regulatory submissions and interactions
• Oversee CROs and pharmacometric vendors
• Collaborate with cross-functional teams in clinical development, regulatory affairs, biostatistics, and non-clinical sciences

Qualifications

• Ph.D., Pharm.D., or equivalent in Clinical Pharmacology or related field
• 12+ years in industry, with proven experience supporting global regulatory submissions and working in early and late-phase development
• Expertise in pharmacokinetics, pharmacodynamics, modeling/simulation tools (e.g., NONMEM, Phoenix WinNonlin) desirable
• Preferred experience includes rare disease, combination therapy, obesity, metabolic, endocrinology, or pediatric development

The position reports to the CMO, requires hybrid work in Boston with some travel, and offers an estimated salary range of $210,000-$300,000.