Senior Director, Clinical Pharmacology — Rare Disease

Rhythm Pharmaceuticals, Inc; Boston (MA); Hybrid; USD 210,000 - 300,000; Full time

Benefits offered by this job

Discretionary bonus

Restricted stock units (RSUs)

Job summary

Rhythm Pharmaceuticals, Inc. is seeking a Senior Director of Clinical Pharmacology to shape and execute the pharmacology strategy across early and late-phase programs. You will lead cross-functional teams, interact with regulatory authorities, and drive dose selection and exposure–response analyses.

The role is based in Boston with a hybrid work model; travel may be required. A strong track record in regulatory submissions and pediatric development is highly valued.

Qualifications

• PhD/PharmD or equivalent required.
• 12+ years of experience in clinical pharmacology in industry with early- and late-phase development.
• Experience in rare disease or orphan drug programs and pediatric extrapolation preferred.
• Deep knowledge of regulatory requirements and global health authority expectations.
• Proven ability to lead cross-functional teams and regulatory interactions.
• Experience with population PK/PD modeling and simulation tools.
• Ability to deliver regulatory submissions and interact with agencies.

Responsibilities

• Lead and define the clinical pharmacology strategy for programs (mono- and combination-therapy).
• Interface with DMPK and translational teams to inform design and PK/PD predictions.
• Design, execute, and interpret clinical pharmacology studies across Ph1–Ph3.
• Develop model-informed drug development strategies to optimize dose selection.
• Collaborate with clinical, regulatory, biostatistics, and non-clinical teams for alignment.
• Author and review regulatory documents and represent pharmacology in agency interactions.
• Lead strategy supporting global registration and lifecycle management.
• Provide leadership in evaluating PK/PD data for clinical decisions.
• Present Rhythm at conferences, advisory boards, and with external experts.
• Advise CMO and Clinical Leadership on pharmacology, translational medicine, and portfolio decisions.
• Oversee CROs, pharmacometrics consultants, and bioanalytical vendors.
• Help build infrastructure, partnerships, and SOPs to grow pharmacology capabilities.

Skills

12+ years experience

Regulatory submissions

Cross-functional leadership

Communication skills

Rare disease/orphan drug experience

Pediatric development exposure

Regulatory knowledge (ICH)

PK/PD modeling familiarity

Education

PhD/PharmD or equivalent

Tools

NONMEM

Phoenix WinNonlin

R

Simcyp

Job description

Rhythm Pharmaceuticals, Inc. is seeking a Senior Director of Clinical Pharmacology to shape and execute the pharmacology strategy across early and late-phase programs. You will lead cross-functional teams, interact with regulatory authorities, and drive dose selection and exposure–response analyses.

The role is based in Boston with a hybrid work model; travel may be required. A strong track record in regulatory submissions and pediatric development is highly valued.