Director, Patient-Centered Science: COA/PRO Strategy

AstraZeneca GmbH; Boston (MA); On-site; USD 194,147 - 291,220; Full time

Job summary

AstraZeneca GmbH is seeking a Patient-Centered Science Director to lead COA/PRO evidence strategies across therapy areas, focusing on patient experience data throughout development and lifecycle. You will guide cross-functional teams to define appropriate COA/PRO endpoints, identify evidence gaps, and translate insights into robust recommendations for regulatory discussions and submissions.

The role drives strategy from early development through late-stage programs, aligning patient-centered

Qualifications

• Bachelor’s degree in a clinical, biological, social science, or related field.
• Master’s degree in outcomes research, epidemiology, health services research, health policy, or a related discipline.
• Doctoral degree (MD preferred).
• At least 5 years’ experience in the biopharmaceutical industry.
• Demonstrated experience in COA/PRO or broader patient-centered science.
• Strong understanding of clinical development, study design, and evidence interpretation.
• Knowledge of qualitative and quantitative methods relevant to patient insight and outcome measurement.
• Experience working across functions and with external vendors/agencies.

Responsibilities

• Lead PCS strategy for assigned therapy areas and projects, covering COA, PRO, and patient experience evidence needs across development.
• Advise teams on endpoint strategy, including selection, development, validation, and implementation of fit-for-purpose instruments.
• Identify evidence gaps and define plans to generate robust patient-centered evidence for regulatory, payer, and clinical decision-making.
• Provide input to clinical development plans, TPPs/TPCs, protocols, briefing books, and regulatory submission packages.
• Lead PCS regulatory and HTA interactions related to PRO/COA evidence and support market-access evidence needs where relevant.
• Generate patient insight through interviews and other research approaches to inform strategy and documentation.
• Partner cross-functionally with R&D, Medical, Payer, Regulatory, and external experts to align evidence plans and messaging.
• Manage external vendors and subprojects, including scope, budget, timelines, quality, and deliverables.
• Drive scientific communication, including presentations, publications, and external engagement to advance AZ’s leadership in PCS.

Skills

PRO/COA strategy

Regulatory knowledge

Stakeholder management

Scientific leadership

Education

Bachelor’s degree in clinical/biological/social science

Master’s degree in outcomes research/epidemiology/health policy

Doctoral degree (MD preferred)

Job description

AstraZeneca GmbH is seeking a Patient-Centered Science Director to lead COA/PRO evidence strategies across therapy areas, focusing on patient experience data throughout development and lifecycle. You will guide cross-functional teams to define appropriate COA/PRO endpoints, identify evidence gaps, and translate insights into robust recommendations for regulatory discussions and submissions.

The role drives strategy from early development through late-stage programs, aligning patient-centered