Director, Oligonucleotide Chemistry & Scale-Up

Lilly; Indianapolis (IN); On-site; USD 153,000 - 264,000; Full time

Benefits offered by this job

Company bonus

401(k) plan

Benefits package

Well-being program

Job summary

Lilly Genetic Medicines in Indianapolis seeks a Director of Oligonucleotide Chemistry to lead the scale-up team responsible for large‑scale oligonucleotide synthesis for RNAi therapeutic candidates. You will guide interdisciplinary efforts with CMC, Development, and discovery chemistry to ensure on‑time delivery of critical materials.

The role demands a PhD with 5+ years in oligonucleotide synthesis, strong leadership, and a track record in method development and team mentorship.

Qualifications

• PhD in Chemistry, Biochemistry or related field with 5+ years of oligonucleotide synthesis experience.
• Strong leadership and mentoring skills for supervising scientists.
• Experience with synthetic organic chemistry and nucleic acid chemistry.

Responsibilities

• Lead the oligosynthesis scale-up team to accelerate RNAi therapeutics from discovery to development.
• Collaborate with CMC and Development to plan material generation and resource needs.
• Develop and improve synthesis methods and adopt new instrumentation and workflows.

Skills

Oligonucleotide synthesis

Team leadership

RNAi discovery

Interdisciplinary collaboration

Education

PhD in Chemistry/Biochemistry

Tools

AKTA

LC-MS

UPLC

Job description

Lilly Genetic Medicines in Indianapolis seeks a Director of Oligonucleotide Chemistry to lead the scale-up team responsible for large‑scale oligonucleotide synthesis for RNAi therapeutic candidates. You will guide interdisciplinary efforts with CMC, Development, and discovery chemistry to ensure on‑time delivery of critical materials.

The role demands a PhD with 5+ years in oligonucleotide synthesis, strong leadership, and a track record in method development and team mentorship.