Director, Oligonucleotide Chemistry & AI-Driven Discovery

BioSpace; Indianapolis (IN); On-site; USD 153,000 - 264,000; Full time

Benefits offered by this job

Bonus potential

401(k) plan

Comprehensive benefits

Job summary

Lilly in Indianapolis seeks a senior oligonucleotide discovery scientist to lead a team of Ph.D.-level researchers. You will design and optimize siRNA, ASOs, and conjugates, integrate AI/ML into discovery, and partner with legal on IP strategy.

The role emphasizes people development through mentorship and inclusive leadership, collaboration across Therapeutic Areas, and delivering candidates to the clinic. We value rigorous data-driven decisions and a strong publication track record; competitive

Qualifications

• Ph.D. in chemistry or related field with 7–10+ years of industry oligonucleotide discovery experience.
• Strong track record delivering drugs to the clinic and collaboration across teams.
• Experience with AI/ML integration in discovery and IP strategy.

Responsibilities

• Hire, develop, and supervise a team of Ph.D.- and associate-level scientists.
• Lead screening, design, and SAR optimization of oligonucleotide constructs to advance candidates.
• Support the integration of AI/ML into discovery efforts.
• Partner with legal to support IP strategy for assigned programs.
• Present results clearly to teams and internal stakeholders.
• Advance technical capabilities and embrace new technologies.
• Demonstrate learning agility and cross-disciplinary insights.
• Maintain strong communication, organizational, and leadership skills.
• Prioritize safety and foster an interdependent safety culture.

Skills

Leadership

Communication

Mentorship

Data-driven design

Analytical thinking

Education

Ph.D. in chemistry

Job description

Lilly in Indianapolis seeks a senior oligonucleotide discovery scientist to lead a team of Ph.D.-level researchers. You will design and optimize siRNA, ASOs, and conjugates, integrate AI/ML into discovery, and partner with legal on IP strategy.

The role emphasizes people development through mentorship and inclusive leadership, collaboration across Therapeutic Areas, and delivering candidates to the clinic. We value rigorous data-driven decisions and a strong publication track record; competitive